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0MTA2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMTA2
DescriptionMetastasis-associated protein mta2 (metastasis-associated 1-like 1) (mta1-l1 protein) (p53 target protein in deacetylase complex).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000118 histone deacetylase complex (TAS)
0006333 chromatin assembly or disassembly (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex . The domain is usually found to the N terminus of a myb-like DNA binding domain and a GATA binding domain. ELM2.n some instances.s also found associated with the ARID DNA binding domain . This suggests that ELM2 may also be involved in DNA binding.r perhaps is a protein-protein interaction domain.
  IPR000949:ELM2
The BAH (bromo-adjacent homology) family contains proteins such as eukaryotic DNA (cytosine-5) methyltransferases .he origin recognition complex 1 (Orc1) proteins.s well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialized in gene silencing.s suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH module might therefore play an important role by linking DNA methylation.eplication and transcriptional regulation .
  IPR001025:Bromo adjacent region
The retroviral oncogene v-myb.nd its cellular counterpart c-myb.ncode nuclear DNA-binding proteins. These belong to the SANT domain family that specifically recognize the sequence YAAC(G/T)G . In myb.ne of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding .
  IPR001005:Myb, DNA-binding
A number of transcription factors (including erythroid-specific transcription factor and nitrogen regulatoryproteins).pecifically bind the DNA sequence (A/T)GATA(A/G) in the regulatory regions of genes.They are consequently termed GATA-binding transcription factors. The interactions occur via highly-conservedzinc finger domains in which the zinc ion is coordinated by 4 cysteine residues .NMR studies have shown the core of the zinc finger to comprise 2 irregular anti-parallel beta-sheets and analpha-helix.ollowed by a long loop to the C-terminal end of the finger. The N-terminal part.hich includesthe helix.s similar in structure.ut not sequence.o the N-terminal zinc module of the glucocorticoidreceptor DNA-binding domain. The helix and the loop connecting the 2 beta-sheets interact with the majorgroove of the DNA.hile the C-terminal tail wraps around into the minor groove. It is this tail that is theessential determinant of specific binding. Interactions between the zinc finger and DNA are mainly hydrophobic.xplaining the preponderance of thymines in the binding site; a large number of interactions with thephosphate backbone have also been observed .Two GATA zinc fingers are found in the GATAtranscription factors. However there are several proteins which only contains a single copy of the domain.
  IPR000679:Zinc finger, GATA-type
IPR001025:BAH 
Evalue:-33.4436974992327 
Location:4-144IPR000949:ELM2 
Evalue:-22.1426677703857 
Location:145-206IPR000679:ZnF_GATA 
Evalue:-14.9208187539524 
Location:361-415IPR001005:Myb_DNA-binding 
Evalue:-9.4814863204956 
Location:265-311IPR000679:GATA_ZN_FINGER_2 
Evalue:0 
Location:0-0
SequencesProtein: MTA2_HUMAN (668 aa)
mRNA: NM_004739
Local Annotation
Synapse Ontology
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 280 residues, 62117250-62118088Exon2: 51 residues, 62118306-62118455Exon3: 41 residues, 62118563-62118682Exon4: 32 residues, 62119028-62119118Exon5: 78 residues, 62119311-62119540Exon6: 48 residues, 62119799-62119939Exon7: 34 residues, 62120057-62120155Exon8: 21 residues, 62120326-62120385Exon9: 27 residues, 62120505-62120580Exon10: 65 residues, 62120684-62120873Exon11: 35 residues, 62121363-62121463Exon12: 36 residues, 62121657-62121760Exon13: 41 residues, 62122071-62122189Exon14: 23 residues, 62122374-62122438Exon15: 41 residues, 62122569-62122687Exon16: 33 residues, 62124213-62124307Exon17: 24 residues, 62124669-62124737Exon18: 138 residues, 62125470-62125879Exon19: 2 residues, -Jump to MTA2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2668 62137198-62139162 ~-2K 6915(ROM1)(+)Loci: 3955 62148876-62170680 ~-22K 6917(GANAB)(-)Loci: 2669 62252159-62262681 ~-11K 6930(+)Loci: 3956 62330945-62356116 ~-25K 6938(STX5A)(-)Loci: 2670 62380093-62412928 ~-33K 6943(SLC3A2)(+)Loci: 3957 62432727-62445588 ~-13K 6949(CHRM1)(-)Loci: 3954 62117250-62125879 ~-9K 6910(MTA2)(-)Link out to UCSC