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0MSHR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMC1R
DescriptionMelanocyte stimulating hormone receptor (msh-r) (melanotropin receptor) (melanocortin-1 receptor) (mc1-r).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004977 melanocortin receptor activity (TAS)
0007275 development (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0009650 UV protection (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Melanocyte-stimulating hormones (MSH).drenocorticotrophin (ACTH) andbeta-endorphin are peptide products of pituitary pro-opiomelanocortin.MSH has a trophic action on melanocytes.nd regulates pigment productionin fish and amphibia. The MSH receptor is expressed in high levels inmelanocytes.elanomas and their derived cell lines . Receptors arefound in low levels in the CNS. MSH regulates temperature control in theseptal region of the brain and releases prolactin from the pituitary.
  IPR000761:Melanocyte-stimulating hormone receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Adrenocorticotrophin (ACTH).elanocyte-stimulating hormones (MSH) andbeta-endorphin are peptide products of pituitary pro-opiomelanocortin.ACTH regulates synthesis and release of glucocorticoids and aldosteronein the adrenal cortex; it also has a trophic action on these cells.ACTH and beta-endorphin are synthesised and released in response tocorticotrophin-releasing factor at times of stress (heat.old.nfections.tc.) - their release leads to increased metabolism and analgesia res..MSH has a trophic action on melanocytes.nd regulates pigment productionin fish and amphibia . The ACTH receptor is found in high levels inthe adrenal cortex - binding sites are present in lower levels in theCNS. The MSH receptor is expressed in high levels in melanocytes.elanomas and their derived cell lines . Receptors are found in lowlevels in the CNS. MSH regulates temperature control in the septal regionof the brain and releases prolactin from the pituitary.
  IPR001671:Melanocortin/ACTH receptor
IPR000276:7tm_1 
Evalue:-36.9586067199707 
Location:55-298IPR000761:MELNOCYTESHR 
Evalue:0 
Location:5-20IPR000761:MELNOCYTESHR 
Evalue:0 
Location:36-49IPR001671:MCRFAMILY 
Evalue:0 
Location:302-315
SequencesProtein: MSHR_HUMAN (317 aa)
mRNA: NM_002386
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK04199
  Level 3 annotation:
    melanocortin 1 receptor
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 787 residues, 88512526-88514885Exon2: 2 residues, -Jump to MSHR_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4242 88238345-88251532 ~-13K 14727(PCOLN3)(-)Loci: 4243 88331459-88410566 ~-79K 14740(FANCA)(-)Loci: 2961 88512526-88514885 ~-2K 14748(MC1R)(+)Loci: 2962 88572761-88590532 ~-18K 14760(AFG3L1)(+)Loci: 2963 88616508-88638880 ~-22K 14764(GAS8)(+)Loci: 2960 88102305-88151674 ~-49K 14720(SPG7)(+)Link out to UCSC