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0MRP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMARCKSL1
DescriptionMarcks-related protein (marcks-like protein 1) (macrophage myristoylated alanine-rich c kinase substrate) (mac-marcks) (macmarcks).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Myristoylated alanine-rich C-kinase substrate (MARCKS) is a predominent cellular substrate for protein kinase C (PKC) that has been implicated in the regulation of brain development.acrophage activation.euro-secretion and growth factor-dependent mitogenesis . The N-terminal glycine is the site of myristoylation.hich allows effective binding of the protein to the plasma membrane.here it co-localises with PKC . MARCKS binds calmodulin in a calcium-dependent manner; the region responsible for calcium-binding is highly basic. domain of about 25 amino acids known as the PSD or effector domain.hich also contains the PKC phosphorylation sites and has been shown to contribute to membrane binding. When not phosphorylated.he effector domain can bind to filamentous actin . It is believed that MARCKS may be a regulated crossbridge between actin and the plasma membrane; modulation of the actin cross-linking activity by calmodulin and phosphorylation.epresent a potential convergence of the calcium-calmodulin and PKC signal transduction pathways in regulation of the actin cytoskeleton. MARCKS also contains an MH2 domain of unknown function. MARCKS-related protein (MRP) is similar to MARCKS in terms of properties such as its myristoylation.hosphorylation and calmodulin-binding.nd shares a high degree of sequence similarity. The two regions that show the highest similarity are the kinase C phosphorylation site domain and the N-terminal region containing the myristoylation site . MARCKS and MRP amino acid compositions are similar.ut the alanine content of the latter is lower. MARCKS proteins appear to adopt a native unfolded conformation i.e. as randomly folded chains arranged in non-classical extended conformations.n common with other substrates of PKC.
  IPR002101:Myristoylated alanine-rich C-kinase substrate MARCKS
IPR002101:MARCKS 
Evalue:-10.6777811050415 
Location:1-41IPR002101:MARCKS_2 
Evalue:0 
Location:83-110IPR002101:MARCKS 
Evalue:0 
Location:174-185
SequencesProtein: MRP_HUMAN (194 aa)
mRNA: NM_023009
Local Annotation
Synapse Ontology
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 420 residues, 32572027-32573285Exon2: 94 residues, 32574134-32574410Exon3: 2 residues, -Jump to MRP_HUMAN  
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Loci Cluster (Details)Loci: 3788 31965305-32002223 ~-37K 944(BAI2)(-)Loci: 2501 32417931-32436472 ~-19K 964(TXLNA)(+)Loci: 2502 32489505-32524350 ~-35K 978(LCK)(+)Loci: 3789 32572027-32574410 ~-2K 982(MARCKSL1)(-)Loci: 2500 31857227-31865301 ~-8K 939(HCRTR1)(+)Link out to UCSC