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0MRP3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameABCC3
DescriptionCanalicular multispecific organic anion transporter 2 (multidrug resistance-associated protein 3) (multi-specific organic anion tranporter-d) (moat-d).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0005524 ATP binding (TAS)
0042626 ATPase activity, coupled to transmembrane m... (TAS)
0008514 organic anion transporter activity (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
ATP-binding cassette (ABC) transporters are multidomain membrane proteins.esponsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. They are minimally composed of four domains.ith two transmembrane domains (TMDs) responsible for allocrite binding and transport and two nucleotide-binding domains (NBDs) responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs. Both NBDs are capable of ATP hydrolysis.nd inhibition of hydrolysis at one NBD effectively abrogates hydrolysis at the other. Hydrolysis at the two NBDs may occur in an alternative fashion although they appear substantially functionally symmetrical in terms of their binding to diverse nucleotides .A variety of ATP-binding transport proteins have a six transmembranehelical region. They are all integral membrane proteinsinvolved in a variety of transport systems. Members of this family include; thecystic fibrosis transmembrane conductance regulator (CFTR).acterial leukotoxinsecretion ATP-binding protein.ultidrug resistance proteins.he yeast leptomycin Bresistance protein.he mammalian sulphonylurea receptor and antigen peptidetransporter 2. Many of these proteins have two such regions.
  IPR001140:ABC transporter, transmembrane region
AAA ATPases form a large.unctionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases.hich exert their activity through the energy-dependent unfolding of macromolecules. AAA ATPases contain a P-loop NTPase domain.hich is the most abundant class of NTP-binding protein fold.nd is found throughout all kingdoms of life . P-loop NTPase domains act to hydrolyse the beta-gamma phosphate bond of bound nucleoside triphosphate. There are two classes of P-loop domains: the KG (kinase-GTPase) division.nd the ASCE division.he latter including the AAA+ group as well as several other ATPases.There are at least six major clades of AAA domains (metalloproteases.eiotic proteins.1 and D2 domains of ATPases with two AAA domains.roteasome subunits.nd BSC1).s well as several minor clades.ome of which consist of hypothetical proteins . The domain organisation of AAA ATPases consists of a non-ATPase N-terminal domain that acts in substrate recognition.ollowed by one or two AAA domains (D1 and D2).ne of which may be degenerate.
  IPR003593:AAA ATPase
ATP-binding cassette (ABC) transporters are multidomain membrane proteins.esponsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. They are minimally composed of four domains.ith two transmembrane domains (TMDs) responsible for allocrite binding and transport and two nucleotide-binding domains (NBDs) responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs. Both NBDs are capable of ATP hydrolysis.nd inhibition of hydrolysis at one NBD effectively abrogates hydrolysis at the other. Hydrolysis at the two NBDs may occur in an alternative fashion although they appear substantially functionally symmetrical in terms of their binding to diverse nucleotides .On the basis of sequence similarities a family of related ATP-binding proteins has been characterized . The proteins belonging to this family also contain one or two copies of the A consensus sequence or the P-loop (see ).
  IPR003439:ABC transporter related
ATP-binding cassette (ABC) transporters are multidomain membrane proteins.esponsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. They are minimally composed of four domains.ith two transmembrane domains (TMDs) responsible for allocrite binding and transport and two nucleotide-binding domains (NBDs) responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs. Both NBDs are capable of ATP hydrolysis.nd inhibition of hydrolysis at one NBD effectively abrogates hydrolysis at the other. Hydrolysis at the two NBDs may occur in an alternative fashion although they appear substantially functionally symmetrical in terms of their binding to diverse nucleotides . This family consists of multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to the ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux reduced its function. The C-terminal domain seems to be highly conserved.
  IPR005292:Multi drug resistance-associated protein (MRP)
IPR003439:ABC_tran 
Evalue:-46.1426658630371 
Location:1316-1499IPR001140:ABC_membrane 
Evalue:-45.0362129211426 
Location:971-1244IPR003439:ABC_tran 
Evalue:-38.2839965820313 
Location:654-827IPR001140:ABC_membrane 
Evalue:-34.4202156066895 
Location:311-582
SequencesProtein: MRP3_HUMAN (1527 aa)
mRNA: NM_003786
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK05667
  Level 3 annotation:
    ATP-binding cassette, subfamily C (CFTR/MRP), member 3
  Level 2 annotation:
    ABC transporters
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 46067226-46067341Exon2: 61 residues, 46088191-46088368Exon3: 44 residues, 46089061-46089187Exon4: 48 residues, 46089405-46089543Exon5: 44 residues, 46090441-46090567Exon6: 22 residues, 46090794-46090856Exon7: 46 residues, 46091596-46091728Exon8: 66 residues, 46093282-46093474Exon9: 61 residues, 46096040-46096218Exon10: 56 residues, 46096309-46096471Exon11: 33 residues, 46097512-46097605Exon12: 70 residues, 46099913-46100117Exon13: 51 residues, 46100222-46100369Exon14: 31 residues, 46100789-46100877Exon15: 24 residues, 46101212-46101279Exon16: 44 residues, 46101499-46101626Exon17: 61 residues, 46101711-46101888Exon18: 58 residues, 46105330-46105498Exon19: 65 residues, 46105828-46106018Exon20: 40 residues, 46107721-46107836Exon21: 50 residues, 46107990-46108135Exon22: 71 residues, 46108242-46108450Exon23: 105 residues, 46108637-46108948Exon24: 68 residues, 46110103-46110303Exon25: 44 residues, 46110452-46110579Exon26: 36 residues, 46112157-46112259Exon27: 51 residues, 46115969-46116116Exon28: 55 residues, 46116308-46116467Exon29: 57 residues, 46117068-46117235Exon30: 67 residues, 46119895-46120090Exon31: 205 residues, 46123451-46124061Exon32: 2 residues, -Jump to MRP3_HUMAN  
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Loci Cluster (Details)Loci: 4299 45545034-45562166 ~-17K 16176(-)Loci: 3018 45598389-45608288 ~-10K 16177(SGCA)(+)Loci: 4300 45800227-45805561 ~-5K 16185(MRPL27)(-)Loci: 3019 45965097-45975160 ~-10K 16195(EPN3)(+)Loci: 3020 45993447-46059430 ~-66K 16202(CACNA1G)(+)Loci: 3021 46067226-46124061 ~-57K 16218(ABCC3)(+)Loci: 3017 45527694-45543421 ~-16K 16175(PDK2)(+)Link out to UCSC