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0MPRD_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameM6PR
DescriptionCation-dependent mannose-6-phosphate receptor precursor (cd man-6-p receptor) (cd-mpr) (46 kda mannose 6-phosphate receptor) (mpr 46).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0009986 cell surface (IEP)
0005887 integral to plasma membrane (TAS)
0004888 transmembrane receptor activity (TAS)
0008333 endosome to lysosome transport (TAS)
0006898 receptor mediated endocytosis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The cation dependent mannose-6-phosphate (man-6-P) receptor is one of two transmembrane proteins involved in the transport of lysosomal enzymes from the Golgi complex and the cell surface to lysosomes . Lysosomal enzymes bearing phosphomannosyl residues bind specifically to man-6-P receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment.here the low pH mediates dissociation of the complex. Binding is optimal in the presence of divalent cations. The amino acid sequence is a single polypeptide chain that contains a putative signal sequence and a transmembrane domain . The cation-dependent mannose 6-phosphate (M6P) receptor (CD-MPR) is present predominantly as a stable homodimer in membranes and has a single M6P-binding site per polypeptide . The molecule crystallizes as a homodimer with approximately 20% of the entire surface area of each monomer having contact with another through predominantly hydrophobic interactions . Each monomer contains a single alpha-helix near its amino terminus followed by nine primarily anti-parallel beta-strands that form two beta-sheets.hich are positioned orthogonally to each other. Extensive hydrophobic interactions are formed between the two beta-sheets.hich results in each monomer forming a flattened beta-barrel structure. Six cysteine residues form three intramolecular disulphide bonds that are essential for the ligand-binding conformation of the receptor to be generated. The structures of the liganded molecules show that the carbohydrate-recognition domain of the enzyme lies relatively deep inside the protein.o that the terminal M6P residue and the penultimate sugar ring of bound pentamannosyl phosphate are mostly buried in the receptor. This deep binding pocket facilitates the formation of numerous interactions between the CD-MPR and its carbohydrate ligands.
  IPR000296:Cation-dependent mannose-6-phosphate receptor
Mannose-6-phosphate receptors (MPRs) are transmembrane proteins involved in the transport of lysosomal enzymes from the Golgi complex and the cell surface to lysosomes . Lysosomal enzymes bearing phosphomannosyl residues bind specifically to MPRs in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment.here the low pH mediates dissociation of the complex. There are two distinct MPRs that function in the recognition of mannose-6-phosphate-containing proteins: the cation-dependent MPR (CD-MPR) and the cation-independent MPR (CI-MPR). The CI-MPR is also known as the insulin-like growth factor II receptor. multi-functional protein implicated in tumour suppression. The crystal structure of the N-terminal.xtracytoplasmic.eceptor-binding domain of bovine CD-MPR (excluding the signal sequence) reveals structural similarity to the fifteen homologous.epeating domains comprising the extracellular region of human CI-MPR . The structure consists of a partly opened.ine-stranded.eta-barrel. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009011:Mannose-6-phosphate receptor, binding
IPR000296:Man-6-P_recep 
Evalue:-248 
Location:1-277
SequencesProtein: MPRD_HUMAN (277 aa)
mRNA: NM_002355
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 525 residues, 8984231-8985803Exon2: 44 residues, 8986278-8986405Exon3: 45 residues, 8987267-8987398Exon4: 38 residues, 8987663-8987773Exon5: 57 residues, 8989280-8989447Exon6: 61 residues, 8990091-8990268Exon7: 58 residues, 8993350-8993519Exon8: 2 residues, -Jump to MPRD_HUMAN  
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