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0MPP5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMPP5
DescriptionMaguk p55 subfamily member 5.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry represents a domain found in guanylate kinase () and in L-type calcium channel.Guanylate kinase () (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP.It is essential for recycling GMP and indirectly.GMP. In prokaryotes (such as Escherichia coli).ower eukaryotes(such as yeast) and in vertebrates.K is a highly conserved monomeric protein of about 200 amino acids. GKhas been shown to be structurally similar to protein A57R (or SalG2R)from various strains of Vaccinia virus. L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel.ince they form the drug binding domain. Other properties.uch as gating voltage-dependence. protein modulation and kinase susceptibility.re influenced by alpha-2.elta and beta subunits.
  IPR008145:Guanylate kinase/L-type calcium channel region
Guanylate kinase () (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP.It is essential for recycling GMP and indirectly.GMP. In prokaryotes (such as Escherichia coli).ower eukaryotes(such as yeast) and in vertebrates.K is a highly conserved monomeric protein of about 200 amino acids. GKhas been shown to be structurally similar to protein A57R (or SalG2R)from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain.n SH3 domain as well as a C-terminal GK-likedomain.re collectively termed MAGUKs (membrane-associated guanylate kinase homologs) .ndinclude Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junctionprotein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail ofNMDA receptor subunits (SAP90/PSD-95.HAPSYN-110/PSD-93.AP97/DLG1 and SAP102); vertebrate 55 kD erythrocytemembrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There isan ATP-binding site (P-loop) in the N-terminal section of GK.hich is not conserved in the GK-like domain ofthe above proteins. However these proteins retain the residues known.n GK.o be involved in the binding ofGMP.
  IPR008144:Guanylate kinase
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. These were first described in the Src cytoplasmic tyrosine kinase . The structure is a partly opened beta barrel.
  IPR011511:Variant SH3
The L27 domain is found in receptor targeting proteins Lin-2 and Lin-7.s well as some protein kinases and human MPP2 protein.
  IPR004172:L27
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
IPR008145:GuKc 
Evalue:-62.9586073148418 
Location:478-663IPR001478:PDZ 
Evalue:-12.3767509460449 
Location:256-333IPR011511:SH3_2 
Evalue:-11.8239088058472 
Location:349-415IPR004172:L27 
Evalue:-7.60205999132796 
Location:186-238IPR004172:L27 
Evalue:-7.16749108729376 
Location:123-180
SequencesProtein: MPP5_HUMAN (675 aa)
mRNA: NM_022474
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords)
?
sdb:0247 cytoskeleton protein transport  (Evidence:keywords)
the formation of new synapse
sdb:0316 synapse formation  (Evidence:keywords)
KO assignmentK06091
  Level 3 annotation:
    membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
  Level 2 annotation:
    Tight junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 77 residues, 66777773-66778003Exon2: 29 residues, 66806170-66806253Exon3: 175 residues, 66815487-66816007Exon4: 71 residues, 66828980-66829189Exon5: 28 residues, 66837858-66837936Exon6: 51 residues, 66838441-66838588Exon7: 56 residues, 66838879-66839041Exon8: 28 residues, 66839991-66840069Exon9: 63 residues, 66848996-66849180Exon10: 26 residues, 66853301-66853373Exon11: 26 residues, 66853877-66853949Exon12: 58 residues, 66856699-66856867Exon13: 69 residues, 66857526-66857729Exon14: 39 residues, 66860171-66860282Exon15: 1015 residues, 66869249-66872288Exon16: 2 residues, -Jump to MPP5_HUMAN  
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Loci Cluster (Details)Loci: 2850 67156331-67188187 ~-32K 11338(ARG2)(+)Loci: 4135 67187618-67211301 ~-24K 11340(VTI1B)(-)Loci: 4136 67213270-67232213 ~-19K 11341(RDH11)(-)Loci: 2849 66777773-66872288 ~-95K 11329(MPP5)(+)Link out to UCSC