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0MPIP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCDC25B
DescriptionM-phase inducer phosphatase 2 (ec 3.1.3.48) (dual specificity phosphatase cdc25b).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005622 intracellular (NAS)
0004725 protein tyrosine phosphatase activity (TAS)
0007067 mitosis (TAS)
0000278 mitotic cell cycle (TAS)
0008284 positive regulation of cell proliferation (TAS)
0000074 regulation of progression through cell cycle (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
M-phase inducer phosphatases function as dosage-dependent inducers in mitotic control . They are tyrosine protein phosphatasesrequired for progression of the cell cycle. They may directly dephosphorylate p34(cdc2) andactivate p34(cdc2) kinase activity. They catalyze the reaction: protein tyrosine phosphate + H2O = protein tyrosine + Pi
  IPR000751:M-phase inducer phosphatase
Rhodanese. sulphurtransferase involved in cyanide detoxification (see ) shares evolutionary relationship with a large family of proteins .ncludingCdc25 phosphatase catalytic domain.non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases.non-catalytic domains of yeast PTP-type MAPK-phosphatases.non-catalytic domains of yeast Ubp4.bp5.bp7.non-catalytic domains of mammalian Ubp-Y.Drosophila heat shock protein HSP-67BB.several bacterial cold-shock and phage shock proteins.plant senescence associated proteins.catalytic and non-catalytic domains of rhodanese (see ).Rhodanese has an internal duplication. This domain is found as a single copy in other proteins.ncluding phosphatases and ubiquitin C-terminal hydrolases .
  IPR001763:Rhodanese-like
IPR000751:M-inducer_phosp 
Evalue:-166.823913574219 
Location:113-384IPR001763:Rhodanese 
Evalue:-36.6777801513672 
Location:424-532IPR000751:MPIPHPHTASE 
Evalue:0 
Location:554-572IPR000751:MPIPHPHTASE 
Evalue:0 
Location:397-414
SequencesProtein: MPIP2_HUMAN (580 aa)
mRNA: NM_021873
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK05866
  Level 3 annotation:
    cell division cycle 25B
  Level 2 annotation:
    MAPK signaling pathway
    Cell cycle
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 327 residues, 3724400-3725378Exon2: 44 residues, 3726268-3726396Exon3: 19 residues, 3727058-3727110Exon4: 16 residues, 3728934-3728976Exon5: 14 residues, 3729108-3729145Exon6: 43 residues, 3729389-3729512Exon7: 43 residues, 3729617-3729740Exon8: 47 residues, 3729900-3730035Exon9: 29 residues, 3730368-3730449Exon10: 61 residues, 3730570-3730747Exon11: 34 residues, 3730927-3731023Exon12: 23 residues, 3731556-3731619Exon13: 35 residues, 3731754-3731853Exon14: 46 residues, 3732050-3732184Exon15: 39 residues, 3733215-3733327Exon16: 432 residues, 3733467-3734759Exon17: 2 residues, -Jump to MPIP2_HUMAN  
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Loci Cluster (Details)Loci: 3232 3817741-3852501 ~-35K 22637(PANK2)(+)Loci: 3233 4100356-4116369 ~-16K 22645(SMOX)(+)Loci: 3231 3724400-3734759 ~-10K 22628(CDC25B)(+)Link out to UCSC