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0MP2K5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAP2K5
DescriptionDual specificity mitogen-activated protein kinase kinase 5 (ec 2.7.1.37) (map kinase kinase 5) (mapkk 5) (mapk/erk kinase 5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0004672 protein kinase activity (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The Phox and Bem1p domain.s present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold.imilar tothat found in ubiquitin and Ras-binding domains. A motif.ariously termed OPR.C and AID.epresents the most conserved region of the majority of PB1 domains.nd is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers.lthough not all PB1 domain pairs associate.
  IPR000270:Octicosapeptide/Phox/Bem1p
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-60.3767509460449 
Location:166-409IPR000270:PB1 
Evalue:-14.3098039627075 
Location:18-97
SequencesProtein: MP2K5_HUMAN (438 aa)
mRNA: NM_002757 NM_145160
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04463
  Level 3 annotation:
    mitogen-activated protein kinase kinase 5
  Level 2 annotation:
    MAPK signaling pathway
    Gap junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 263 residues, 65622074-65622862Exon2: 18 residues, 65629425-65629474Exon3: 24 residues, 65642674-65642742Exon4: 25 residues, 65660145-65660215Exon5: 15 residues, 65665281-65665322Exon6: 24 residues, 65666237-65666305Exon7: 18 residues, 65672317-65672366Exon8: 23 residues, 65680076-65680141Exon9: 15 residues, 65710279-65710319Exon10: 25 residues, 65725622-65725691Exon11: 29 residues, 65725779-65725861Exon12: 22 residues, 65737944-65738006Exon13: 18 residues, 65743988-65744037Exon14: 26 residues, 65771870-65771944Exon15: 19 residues, 65772909-65772960Exon16: 26 residues, 65782728-65782800Exon17: 12 residues, 65807307-65807337Exon18: 11 residues, 65827622-65827649Exon19: 13 residues, 65827960-65827993Exon20: 22 residues, 65848993-65849055Exon21: 17 residues, 65852098-65852144Exon22: 158 residues, 65886037-65886505Exon23: 2 residues, -Jump to MP2K5_HUMANExon1: 263 residues, 65622074-65622862Exon2: 18 residues, 65629425-65629474Exon3: 24 residues, 65642674-65642742Exon4: 25 residues, 65660145-65660215Exon5: 15 residues, 65665281-65665322Exon6: 24 residues, 65666237-65666305Exon7: 18 residues, 65672317-65672366Exon8: 23 residues, 65680076-65680141Exon9: 15 residues, 65710279-65710319Exon10: 25 residues, 65725622-65725691Exon11: 29 residues, 65725779-65725861Exon12: 22 residues, 65737944-65738006Exon13: 18 residues, 65743988-65744037Exon14: 26 residues, 65771870-65771944Exon15: 19 residues, 65772909-65772960Exon16: 26 residues, 65782728-65782800Exon17: 11 residues, 65827622-65827649Exon18: 13 residues, 65827960-65827993Exon19: 22 residues, 65848993-65849055Exon20: 17 residues, 65852098-65852144Exon21: 158 residues, 65886037-65886505Exon22: 2 residues, -Jump to MP2K5_HUMAN  
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