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0MP2K1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAP2K1
DescriptionDual specificity mitogen-activated protein kinase kinase 1 (ec 2.7.1.-) (map kinase kinase 1) (mapkk 1) (erk activator kinase 1) (mapk/erk kinase 1) (mek1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004708 MAP kinase kinase activity (TAS)
0005515 protein binding (IPI)
0004672 protein kinase activity (TAS)
0006928 cell motility (TAS)
0006935 chemotaxis (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-79.537602002101 
Location:67-360
SequencesProtein: MP2K1_HUMAN (392 aa)
mRNA: NM_002755
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK04368
  Level 3 annotation:
    mitogen-activated protein kinase kinase 1
  Level 2 annotation:
    MAPK signaling pathway
    Insulin signaling pathway
    Regulation of actin cytoskeleton
    Focal adhesion
    Gap junction
    Natural killer cell mediated cytotoxicity
    Fc epsilon RI signaling pathway
    Long-term potentiation
    Long-term depression
    Dorso-ventral axis formation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 48 residues, 64466678-64466819Exon2: 72 residues, 64514418-64514629Exon3: 51 residues, 64516137-64516284Exon4: 28 residues, 64522671-64522749Exon5: 19 residues, 64524047-64524099Exon6: 43 residues, 64561146-64561271Exon7: 69 residues, 64564381-64564583Exon8: 23 residues, 64566619-64566684Exon9: 22 residues, 64568606-64568668Exon10: 17 residues, 64569109-64569155Exon11: 349 residues, 64569893-64570935Exon12: 2 residues, -Jump to MP2K1_HUMAN  
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