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0MLN64_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSTARD3
DescriptionMln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0008203 cholesterol metabolism (TAS)
0006629 lipid metabolism (TAS)
0006839 mitochondrial transport (TAS)
0008202 steroid metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
START (StAR-related lipid-transfer) is a lipid-binding domain in StAR.D-ZIP and signalling proteins . StAR (Steroidogenic Acute Regulatory protein) is a mitochondrial protein that is synthesised in response to luteinising hormone stimulation . Expression of the protein in the absence of hormone stimulation is sufficient to induce steroid production.uggesting that this protein is required in the acute regulation of steroidogenesis. Representatives of the START domain family havebeen shown to bind different ligands such as sterols (StAR protein) andphosphatidylcholine (PC-TP). Ligand binding by the START domain can alsoregulate the activities of other domains that co-occur with the START domainin multidomain proteins such as Rho-gap.he homeodomain.nd the thioesterase domain . The crystal structure of START domain of human MLN64 shows analpha/beta fold built around an U-shaped incomplete beta-barrel. Mostimportantly.he interior of the protein encompasses a 26 x 12 x 11 Angstromshydrophobic tunnel that is apparently large enough to bind a singlecholesterol molecule . The START domain structure revealed an unexpectedsimilarity to that of the birch pollen allergen Bet v 1 and to bacterialpolyketide cyclases/aromatases .
  IPR002913:Lipid-binding START
Steroidogenic cells respond to trophic hormone stimulation by mobilisation of cholesterol from cellular stores to the mitochondrial outer membrane.nd thence to the inner membrane.here the first enzymatic step in steroidogenesis occurs. Cholesterol transfer across the membranes isdependent on de novo protein synthesis.hich is the regulated step in the process . The newly-synthesised regulatory protein(s) have yet to be identified. Nevertheless. candidate mitochondrial protein has been characterised that is synthesised in response to luteinising hormone stimulation . Expression of the protein in the absence of hormone stimulation is sufficient to induce steroid production.uggesting that this protein is required in the acute regulation of steroidogenesis. This novel protein has been termed Steroidogenic Acute Regulatory protein (StAR).
  IPR000799:Steroidogenic acute regulatory protein
IPR002913:START 
Evalue:-67.6575775146484 
Location:239-444
SequencesProtein: MLN64_HUMAN (445 aa)
mRNA: NM_006804
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 25 residues, 35046937-35047010Exon2: 92 residues, 35063259-35063529Exon3: 28 residues, 35066786-35066864Exon4: 28 residues, 35067553-35067631Exon5: 20 residues, 35067751-35067805Exon6: 41 residues, 35068183-35068301Exon7: 35 residues, 35068500-35068599Exon8: 20 residues, 35068829-35068885Exon9: 33 residues, 35069239-35069332Exon10: 23 residues, 35069989-35070052Exon11: 34 residues, 35070209-35070305Exon12: 28 residues, 35070588-35070668Exon13: 37 residues, 35070759-35070864Exon14: 33 residues, 35072029-35072123Exon15: 224 residues, 35072582-35073248Exon16: 2 residues, -Jump to MLN64_HUMAN  
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Loci Cluster (Details)Loci: 3000 35036704-35046401 ~-10K 15710(PPP1R1B)(+)Loci: 3001 35046937-35073248 ~-26K 15714(STARD3)(+)Loci: 4284 34583234-34607427 ~-24K 15696(CACNB1)(-)Link out to UCSC