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0MKL2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMKL2
DescriptionMkl/myocardin-like protein 2 (myocardin-related transcription factor b) (mrtf-b) (megakaryoblastic leukemia 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (IC)
0042802 protein self binding (IPI)
0003713 transcription coactivator activity (IDA)
0045844 positive regulation of myogenesis (IDA)
0045944 positive regulation of transcription from R... (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The SAP (after SAF-A/B.cinus and PIAS) motif is a putativeDNA binding domain found in diverse nuclear proteins involved in chromosomal organization .
  IPR003034:DNA-binding SAP
The RPEL repeat is named after four conserved amino acids it contains. The function of the RPEL repeat is unknown however it might be a DNA binding repeat based on the observation that Q9VZY2 contains a SAP domain that is also implicated in DNA binding.
  IPR004018:RPEL repeat
IPR003034:SAP 
Evalue:-12.7447271347046 
Location:389-423IPR004018:RPEL 
Evalue:-7.79588001734407 
Location:128-153IPR004018:RPEL 
Evalue:-4.33724216831843 
Location:40-65IPR004018:RPEL 
Evalue:-3.63827216398241 
Location:84-109
SequencesProtein: MKL2_HUMAN (1088 aa)
mRNA: NM_014048
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 10 residues, 14072696-14072723Exon2: 23 residues, 14080647-14080712Exon3: 74 residues, 14141901-14142118Exon4: 24 residues, 14211600-14211666Exon5: 20 residues, 14213711-14213767Exon6: 27 residues, 14214902-14214978Exon7: 56 residues, 14218483-14218645Exon8: 61 residues, 14220177-14220356Exon9: 48 residues, 14235503-14235641Exon10: 84 residues, 14241594-14241842Exon11: 46 residues, 14246885-14247018Exon12: 297 residues, 14247830-14248715Exon13: 54 residues, 14250283-14250439Exon14: 56 residues, 14253219-14253381Exon15: 48 residues, 14253722-14253860Exon16: 22 residues, 14259458-14259519Exon17: 1956 residues, 14262266-14268130Exon18: 2 residues, -Jump to MKL2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2926 14072696-14268130 ~-195K 13537(MKL2)(+)Loci: 2925 13921541-13949840 ~-28K 13535(ERCC4)(+)Link out to UCSC