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0MK67I_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMKI67IP
DescriptionMki67 fha domain-interacting nucleolar phosphoprotein (nucleolar protein interacting with the fha domain of pki-67) (hnifk) (nucleolar phosphoprotein nopp34).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000794 condensed nuclear chromosome (IDA)
0005737 cytoplasm (IDA)
0005730 nucleolus (IDA)
0005654 nucleoplasm (IDA)
0005515 protein binding (IPI)
0003723 RNA binding (IDA)
0006461 protein complex assembly (NAS)
0016072 rRNA metabolism (NAS)
0009303 rRNA transcription (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM 
Evalue:-20.1191864077192 
Location:46-119
SequencesProtein: MK67I_HUMAN (293 aa)
mRNA: NM_032390
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 312 residues, 122201023-122201958Exon2: 25 residues, 122202333-122202402Exon3: 22 residues, 122202522-122202582Exon4: 72 residues, 122204938-122205150Exon5: 38 residues, 122206141-122206250Exon6: 48 residues, 122209658-122209796Exon7: 51 residues, 122210791-122210938Exon8: 2 residues, -Jump to MK67I_HUMAN  
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Loci Cluster (Details)Loci: 4461 122201023-122210938 ~-10K 21205(MKI67IP)(-)Loci: 4460 121811824-122123522 ~-312K 21204(CLASP1)(-)Link out to UCSC