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0MK10_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAPK10
DescriptionMitogen-activated protein kinase 10 (ec 2.7.1.37) (stress-activated protein kinase jnk3) (c-jun n-terminal kinase 3) (map kinase p49 3f12).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004705 JUN kinase activity (ISS)
0004708 MAP kinase kinase activity (TAS)
0007254 JNK cascade (ISS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
MAP (Mitogen Activated Protein) kinases participate in kinase cascades.hereby at least 3 protein kinases act in series.ulminating in activationof MAP kinase . MAP kinases are activated by dual phosphorylationon both tyrosine and threonine residues of a conserved TXY motif.JNK (Jun N-terminal Kinase).lso known as Stress Activated Protein Kinase(SAPK).elongs to the family of MAP kinases . JNKs are activated by cytokines.ertain ligands for GPCRs.gentsthat interfere with DNA and protein synthesis.nd to some extent bygrowth factors.erum and transforming agents. Three genes have beenidentified in humans: JNK1.NK2 and JNK3. Knockouts of these genes haverevealed that JNK1 and/or JNK2 must have a role in both apoptosis and the immune response.
  IPR008351:JNK MAP kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-87.3767507096021 
Location:64-359IPR008351:JNKMAPKINASE 
Evalue:0 
Location:362-373IPR000719:PROTEIN_KINASE_ATP 
Evalue:0 
Location:0-0
SequencesProtein: MK10_HUMAN (464 aa)
mRNA: NM_002753 NM_138980 NM_138982
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK04440
  Level 3 annotation:
    c-Jun N-terminal kinase
  Level 2 annotation:
    MAPK signaling pathway
    Wnt signaling pathway
    Insulin signaling pathway
    Adipocytokine signaling pathway
    Focal adhesion
    Toll-like receptor signaling pathway
    Fc epsilon RI signaling pathway
    Type II diabetes mellitus
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 298 residues, 87156656-87157547Exon2: 28 residues, 87169373-87169451Exon3: 23 residues, 87171544-87171608Exon4: 43 residues, 87204442-87204567Exon5: 63 residues, 87207949-87208132Exon6: 26 residues, 87238700-87238772Exon7: 57 residues, 87241228-87241394Exon8: 48 residues, 87242070-87242209Exon9: 21 residues, 87243362-87243421Exon10: 45 residues, 87247399-87247529Exon11: 58 residues, 87299474-87299644Exon12: 35 residues, 87334485-87334584Exon13: 40 residues, 87494706-87494821Exon14: 137 residues, 87499834-87500240Exon15: 2 residues, -Jump to MK10_HUMANExon1: 298 residues, 87156656-87157547Exon2: 28 residues, 87169373-87169451Exon3: 23 residues, 87171544-87171608Exon4: 43 residues, 87204442-87204567Exon5: 63 residues, 87207949-87208132Exon6: 26 residues, 87238700-87238772Exon7: 57 residues, 87241228-87241394Exon8: 48 residues, 87242070-87242209Exon9: 21 residues, 87243362-87243421Exon10: 45 residues, 87247399-87247529Exon11: 58 residues, 87299474-87299644Exon12: 26 residues, 87334512-87334584Exon13: 22 residues, 87494706-87494767Exon14: 2 residues, -Jump to MK10_HUMANExon1: 299 residues, 87156656-87157552Exon2: 28 residues, 87169373-87169451Exon3: 23 residues, 87171544-87171608Exon4: 43 residues, 87204442-87204567Exon5: 63 residues, 87207949-87208132Exon6: 26 residues, 87238700-87238772Exon7: 57 residues, 87241228-87241394Exon8: 48 residues, 87242070-87242209Exon9: 21 residues, 87243362-87243421Exon10: 45 residues, 87247399-87247529Exon11: 58 residues, 87299474-87299644Exon12: 26 residues, 87334512-87334584Exon13: 40 residues, 87494706-87494821Exon14: 35 residues, 87593206-87593307Exon15: 2 residues, -Jump to MK10_HUMAN  
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