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0MK07_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAPK7
DescriptionMitogen-activated protein kinase 7 (ec 2.7.1.37) (extracellular signal-regulated kinase 5) (erk-5) (erk4) (bmk1 kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004707 MAP kinase activity (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-95.6382721639824 
Location:54-346
SequencesProtein: MK07_HUMAN (815 aa)
mRNA: AY534741 NM_139033
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK04464
  Level 3 annotation:
    mitogen-activated protein kinase 7
  Level 2 annotation:
    MAPK signaling pathway
    Gap junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 117 residues, 19221658-19222007Exon2: 81 residues, 19222801-19223038Exon3: 57 residues, 19223687-19223853Exon4: 361 residues, 19224513-19225592Exon5: 230 residues, 19225686-19226372Exon6: 46 residues, 19226718-19226852Exon7: 155 residues, 19226983-19227444Exon8: 2 residues, -Jump to MK07_HUMANExon1: 81 residues, 19222797-19223038Exon2: 57 residues, 19223687-19223853Exon3: 621 residues, 19224513-19226372Exon4: 46 residues, 19226718-19226852Exon5: 157 residues, 19226983-19227449Exon6: 2 residues, -Jump to MK07_HUMAN  
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Loci Cluster (Details)Loci: 2989 19221658-19227449 ~-6K 15306(MAPK7)(+)Loci: 2990 19492655-19521500 ~-29K 15314(ALDH3A2)(+)Loci: 4273 19749343-19821721 ~-72K 15324(AKAP10)(-)Loci: 2988 19081302-19180620 ~-99K 15297(EPN2)(+)Link out to UCSC