SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0MK01_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAPK1
DescriptionMitogen-activated protein kinase 1 (ec 2.7.1.37) (extracellular signal-regulated kinase 2) (erk-2) (mitogen-activated protein kinase 2) (map kinase 2) (mapk 2) (p42-mapk) (ert1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004707 MAP kinase activity (TAS)
0006935 chemotaxis (TAS)
0006917 induction of apoptosis (TAS)
0006950 response to stress (TAS)
0007165 signal transduction (TAS)
0007268 synaptic transmission (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1426359475.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
MAP (Mitogen Activated Protein) kinases participate in kinase cascades.hereby at least 3 protein kinases act in series.ulminating in activationof MAP kinase . MAP kinases are activated by dual phosphorylationon both tyrosine and threonine residues of a conserved TXY motif.ERKs (Extracellularly Regulated Kinases) belong to the family of MAPkinases. ERK1 and ERK2.roteins of 43 and 41kDa respectively.re ~85%identical.ven higher levels of similarity being seen in substrate bindingregions. Both are ubiquitously expressed.lthough levels vary fromtissue to tissue. They are activated.or example.y serum.rowth factorsand cytokines. They phosphorylate both cytoskeletal proteins andtranscription factors.esulting ultimately in cell growth. Substrates carrya PX(T/S)P motif; other such "docking domains" also exist within ERK.hichinteract with specific motifs in the substrate: e.g..RK1 and ERK2 possess2 DXXD docking sites capable of interaction with a Kinase Interaction Motif(KIM).hich can be found on activators (MAPKK).nhibitors (PTP-SL and dualspecificity phosphatases) and substrates (Elk-1).
  IPR008349:ERK1/2 MAP kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-95.130768280269 
Location:24-312
SequencesProtein: MK01_HUMAN (360 aa)
mRNA: NM_002745 Z11695
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentK04371
  Level 3 annotation:
    extracellular signal-regulated kinase 1/2
  Level 2 annotation:
    MAPK signaling pathway
    TGF-beta signaling pathway
    Insulin signaling pathway
    Regulation of actin cytoskeleton
    Focal adhesion
    Adherens junction
    Gap junction
    Natural killer cell mediated cytotoxicity
    Fc epsilon RI signaling pathway
    Long-term potentiation
    Long-term depression
    Dorso-ventral axis formation
    Axon guidance
    Type II diabetes mellitus
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1528 residues, 20443948-20448529Exon2: 44 residues, 20453483-20453609Exon3: 38 residues, 20457161-20457271Exon4: 46 residues, 20472545-20472677Exon5: 40 residues, 20472982-20473097Exon6: 41 residues, 20483300-20483417Exon7: 65 residues, 20490138-20490328Exon8: 63 residues, 20491952-20492135Exon9: 121 residues, 20551611-20551970Exon10: 2 residues, -Jump to MK01_HUMANExon1: 178 residues, 20446878-20447410Exon2: 317 residues, 20447583-20448529Exon3: 44 residues, 20453483-20453609Exon4: 38 residues, 20457161-20457271Exon5: 46 residues, 20472545-20472677Exon6: 40 residues, 20472982-20473097Exon7: 41 residues, 20483300-20483417Exon8: 65 residues, 20490138-20490328Exon9: 63 residues, 20491952-20492135Exon10: 39 residues, 20551611-20551722Exon11: 2 residues, -Jump to MK01_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3301 20326541-20328587 ~-2K 24274(SDF2L1)(+)Loci: 4561 20443948-20551970 ~-108K 24279(MAPK1)(-)Loci: 3300 20251956-20308323 ~-56K 24268(UBE2L3)(+)Link out to UCSC