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0MIF_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMIF
DescriptionMacrophage migration inhibitory factor (mif) (phenylpyruvate tautomerase) (ec 5.3.2.1) (glycosylation-inhibiting factor) (gif).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (IDA)
0005125 cytokine activity (IDA)
0005515 protein binding (IPI)
0008283 cell proliferation (IDA)
0007166 cell surface receptor linked signal transdu... (IDA)
0043066 negative regulation of apoptosis (IDA)
0001516 prostaglandin biosynthesis (IDA)
0043030 regulation of macrophage activation (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Macrophage migration inhibitory factor (MIF) seems to play an important role in host inflammatory responses where it is involved in the host response to endotoxic shock probably serving as a pituitary "stress" hormone that regulates systemic inflammatory responses . MIF is a secreted protein that is not processed from a larger precursor. D-dopachrome tautomerase.elated to MIF.s a mammalian cytoplasmic enzyme involved in melanin biosynthesis that tautomerizes D-dopachrome with concomitant decarboxylation to give 5.-dihydroxyindole (DHI) .
  IPR001398:Macrophage migration inhibitory factor
IPR001398:MIF 
Evalue:-80.8860549926758 
Location:1-114
SequencesProtein: MIF_HUMAN (114 aa)
mRNA: NM_002415
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 69 residues, 22566564-22566769Exon2: 59 residues, 22566958-22567131Exon3: 63 residues, 22567226-22567409Exon4: 2 residues, -Jump to MIF_HUMAN  
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