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0MGST2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMGST2
DescriptionMicrosomal glutathione s-transferase 2 (ec 2.5.1.18) (microsomal gst- 2) (microsomal gst-ii).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005624 membrane fraction (TAS)
0005792 microsome (TAS)
0004364 glutathione transferase activity (TAS)
0019735 antimicrobial humoral response (sensu Verte... (TAS)
0007267 cell-cell signaling (TAS)
0006691 leukotriene metabolism (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family describes a widespread superfamily of membrane-associated proteins withhighly divergent functions in eicosanoid and glutathione metabolism (MAPEG). Included arethe 5-lipoxygenase activating protein (gene FLAP) that seems to be required for the activation of 5-lipoxygenase.eukotriene C4 synthase () that catalyzes the production of LTC4 from LTA4and microsomal glutathione S-transferase II () (GST-II) that also produces LTC4 from LTA4.
  IPR001129:Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)
5-lipoxygenase-activating protein (FLAP) is an integral membrane protein found in cells that produce leukotrienes.he biologically active metabolites of arachidonic acid that have been implicated in a variety of inflammatory responses.ncluding asthma.rthritis and psoriasis .FLAP appears to activatate 5-lipoxygenase (5LOX) by facilitating its binding to membranes . It binds arachidonic acid.nd may play a role in its transfer to 5LOX. The protein has been shown to bind to MK-886. compound that blocks leukotriene biosynthesis .
  IPR001446:5-lipoxygenase-activating protein
IPR001129:MAPEG 
Evalue:-72.3767471313477 
Location:3-130
SequencesProtein: MGST2_HUMAN (147 aa)
mRNA: NM_002413
Local Annotation
Synapse Ontology
Signal transduction in the postsynaptic neuron
sdb:0016 Signal transduction in the postsynaptic neuron  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 104 residues, 140806371-140806681Exon2: 35 residues, 140819146-140819246Exon3: 25 residues, 140835800-140835871Exon4: 29 residues, 140844058-140844140Exon5: 80 residues, 140844619-140844854Exon6: 2 residues, -Jump to MGST2_HUMAN  
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Loci Cluster (Details)Loci: 3426 140442125-140531385 ~-89K 28199(NARG1)(+)Loci: 3427 140594410-140616513 ~-22K 28200(RAB33B)(+)Loci: 3428 140806371-140844854 ~-38K 28202(MGST2)(+)Loci: 4690 140198320-140280056 ~-82K 28195(ELF2)(-)Link out to UCSC