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0MGR7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGRM7
DescriptionMetabotropic glutamate receptor 7 precursor (mglur7).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0008067 metabotropic glutamate, GABA-B-like recepto... (TAS)
0007194 negative regulation of adenylate cyclase ac... (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.At least eight sub-types of metabotropic receptor (MGR1-8) have beenidentified in cloning studies. The sub-types differ in their agonistpharmacology and signal transduction pathways .
  IPR000162:Metabotropic glutamate receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.
  IPR000337:GPCR, family 3, metabotropic glutamate receptor-like
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane.ethered to in several receptor proteins.
  IPR011500:Nine cysteines of 3 GPCR
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.At least eight sub-types of metabotropic receptor (MGR1-8) have beenidentified in cloning studies. The sub-types differ in their agonistpharmacology and signal transduction pathways .MGR7 mRNA has a widespread distribution in many neuronal cells of the central nervoussystem.ith highest levels in the hippocampal formation.erebral cortexand cerebellum . it is thus different from the more limitedly expressedMGR4 or MGR6 mRNA . MGR7 and MGR4 are believed to correspond to theputative L-2-amino-4-phosphonobutyrate receptor.hich plays an importantrole in modulation of glutamate transmission in the CNS .
  IPR001883:Metabotropic glutamate receptor 7
IPR000337:7tm_3 
Evalue:-138.53759765625 
Location:594-855IPR001828:ANF_receptor 
Evalue:-107.119186401367 
Location:77-485IPR011500:NCD3G 
Evalue:-16.7695503234863 
Location:519-554IPR001883:MTABOTROPC7R 
Evalue:0 
Location:22-42IPR001883:MTABOTROPC7R 
Evalue:0 
Location:873-888IPR000337:GPCRMGR 
Evalue:0 
Location:46-58
SequencesProtein: MGR7_HUMAN (915 aa)
mRNA: NM_000844 NM_181874
Local Annotation
Synapse Ontology
some genes' expression is great dependent on the calcium, so calcium can regulate their expression.
sdb:0199 calcium regulation of transcription  (Evidence:domains)
KO assignmentK04609
  Level 3 annotation:
    glutamate receptor, metabotropic 7
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 223 residues, 6877926-6878594Exon2: 74 residues, 7163138-7163355Exon3: 49 residues, 7315370-7315512Exon4: 53 residues, 7323184-7323339Exon5: 49 residues, 7431709-7431850Exon6: 69 residues, 7469293-7469494Exon7: 48 residues, 7478269-7478409Exon8: 314 residues, 7595108-7596044Exon9: 84 residues, 7696735-7696982Exon10: 32 residues, 7703043-7703135Exon11: 393 residues, 7757043-7758217Exon12: 2 residues, -Jump to MGR7_HUMANExon1: 223 residues, 6877926-6878594Exon2: 74 residues, 7163138-7163355Exon3: 49 residues, 7315370-7315512Exon4: 53 residues, 7323184-7323339Exon5: 49 residues, 7431709-7431850Exon6: 69 residues, 7469293-7469494Exon7: 48 residues, 7478269-7478409Exon8: 314 residues, 7595108-7596044Exon9: 84 residues, 7696735-7696982Exon10: 393 residues, 7757043-7758217Exon11: 2 residues, -Jump to MGR7_HUMAN