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0MGR6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGRM6
DescriptionMetabotropic glutamate receptor 6 precursor (mglur6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0008067 metabotropic glutamate, GABA-B-like recepto... (TAS)
0009584 detection of visible light (TAS)
0007216 metabotropic glutamate receptor signaling p... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.At least eight sub-types of metabotropic receptor (MGR1-8) have beenidentified in cloning studies. The sub-types differ in their agonistpharmacology and signal transduction pathways .
  IPR000162:Metabotropic glutamate receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.
  IPR000337:GPCR, family 3, metabotropic glutamate receptor-like
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane.ethered to in several receptor proteins.
  IPR011500:Nine cysteines of 3 GPCR
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.At least eight sub-types of metabotropic receptor (MGR1-8) have beenidentified in cloning studies. The sub-types differ in their agonistpharmacology and signal transduction pathways .MGR6 is restrictedly expressed in retinal ON bipolar cells and.n the basis of its agonistselectivity.ay have a key physiological role in certain inherited eyediseases .
  IPR000112:Metabotropic glutamate receptor 6
IPR000337:7tm_3 
Evalue:-134.585021972656 
Location:589-850IPR001828:ANF_receptor 
Evalue:-106.853874206543 
Location:67-478IPR011500:NCD3G 
Evalue:-15.5376024246216 
Location:514-547IPR000112:MTABOTROPC6R 
Evalue:0 
Location:20-37IPR000112:MTABOTROPC6R 
Evalue:0 
Location:857-874IPR000112:MTABOTROPC6R 
Evalue:0 
Location:493-510
SequencesProtein: MGR6_HUMAN (877 aa)
mRNA: NM_000843
Local Annotation
Synapse Ontology
some genes' expression is great dependent on the calcium, so calcium can regulate their expression.
sdb:0199 calcium regulation of transcription  (Evidence:domains)
KO assignmentK04608
  Level 3 annotation:
    glutamate receptor, metabotropic 6
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 470 residues, 178337937-178339346Exon2: 701 residues, 178339363-178341461Exon3: 106 residues, 178342516-178342828Exon4: 210 residues, 178345736-178346360Exon5: 50 residues, 178346444-178346590Exon6: 69 residues, 178348541-178348742Exon7: 49 residues, 178348871-178349012Exon8: 53 residues, 178350198-178350353Exon9: 47 residues, 178351030-178351166Exon10: 74 residues, 178351473-178351690Exon11: 229 residues, 178354047-178354730Exon12: 2 residues, -Jump to MGR6_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4760 178337937-178354730 ~-17K 30083(GRM6)(-)Loci: 4759 177962271-177986660 ~-24K 30074(CLK4)(-)Link out to UCSC