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0MGR5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGRM5
DescriptionMetabotropic glutamate receptor 5 precursor (mglur5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0008067 metabotropic glutamate, GABA-B-like recepto... (TAS)
0007206 metabotropic glutamate receptor, phospholip... (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.At least eight sub-types of metabotropic receptor (MGR1-8) have beenidentified in cloning studies. The sub-types differ in their agonistpharmacology and signal transduction pathways .
  IPR000162:Metabotropic glutamate receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.
  IPR000337:GPCR, family 3, metabotropic glutamate receptor-like
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane.ethered to in several receptor proteins.
  IPR011500:Nine cysteines of 3 GPCR
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.At least eight sub-types of metabotropic receptor (MGR1-8) have beenidentified in cloning studies. The sub-types differ in their agonistpharmacology and signal transduction pathways .mRNA for MGR5 is widespread in the brain.ith a unique distribution; it is found in highlevels in the striatum.erebral cortex.ippocampus and olfactory bulb.MGR5 activates the phosphoinositide pathway.robably via a G-protein ofthe Gq/G11 class; pertussis toxin partially inhibits the response to MGR1.ut not to MGR5 .
  IPR000202:Metabotropic glutamate receptor 5
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.At least eight sub-types of metabotropic receptor (MGR1-8) have beenidentified in cloning studies. The sub-types differ in their agonistpharmacology and signal transduction pathways .mRNA for MGR1 is widespread in the brain and is abundant in neuronal cells in hippocampaldentate gyrus and CA2-3 regions.erebellum Purkinje cells.lfactory bulband thalamic nuclei. MGR1 activates the phophoinositide pathway.robably via a G-protein of the Gq/G11 class; pertussis toxin partiallyinhibits the response to MGR1.ut not to MGR5 .
  IPR001256:Metabotropic glutamate receptor 1
IPR000337:7tm_3 
Evalue:-131.060485839844 
Location:583-832IPR001828:ANF_receptor 
Evalue:-99.958610534668 
Location:67-473IPR011500:NCD3G 
Evalue:-17.2757244110107 
Location:507-543IPR000202:MTABOTROPC5R 
Evalue:0 
Location:930-954IPR000202:MTABOTROPC5R 
Evalue:0 
Location:851-874IPR000202:MTABOTROPC5R 
Evalue:0 
Location:1015-1038IPR001256:MTABOTROPC1R 
Evalue:0 
Location:1185-1207IPR001256:MTABOTROPC1R 
Evalue:0 
Location:1153-1172IPR000202:MTABOTROPC5R 
Evalue:0 
Location:17-33
SequencesProtein: MGR5_HUMAN (1212 aa)
mRNA: D28539 NM_000842
Local Annotation
Synapse Ontology
some genes' expression is great dependent on the calcium, so calcium can regulate their expression.
sdb:0199 calcium regulation of transcription  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
KO assignmentK04604
  Level 3 annotation:
    glutamate receptor, metabotropic 5
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
    Gap junction
    Long-term potentiation
    Long-term depression
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 566 residues, 87880625-87882320Exon2: 34 residues, 87898124-87898220Exon3: 315 residues, 87939868-87940808Exon4: 44 residues, 87963416-87963543Exon5: 58 residues, 87969999-87970168Exon6: 84 residues, 87977533-87977780Exon7: 80 residues, 88025983-88026219Exon8: 85 residues, 88222721-88222971Exon9: 272 residues, 88420027-88420838Exon10: 2 residues, -Jump to MGR5_HUMANExon1: 566 residues, 87880625-87882320Exon2: 315 residues, 87939868-87940808Exon3: 44 residues, 87963416-87963543Exon4: 58 residues, 87969999-87970168Exon5: 84 residues, 87977533-87977780Exon6: 80 residues, 88025983-88026219Exon7: 85 residues, 88222721-88222971Exon8: 272 residues, 88420027-88420838Exon9: 2 residues, -Jump to MGR5_HUMAN  
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