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0MFN2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMFN2
DescriptionTransmembrane gtpase mfn2 (ec 3.6.5.-) (mitofusin-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is conserved C-terminal region is found in a number of putative transmembrane GTPase. The Fzo protein is a mediator of mitochondrial fusion . This conserved region is also found in the human mitofusin protein .
  IPR006884:Fzo-like conserved region
Membrane transport between compartments in eukaryotic cells requires proteins that allow the budding and scission of nascent cargo vesicles from one compartment and their targeting and fusion with another. Dynamins are large GTPases that belong to a protein superfamily that.n eukaryotic cells.ncludes classical dynamins.ynamin-like proteins.PA1.x proteins.itofusins and guanylate-binding proteins/atlastins and are involved in the scission of a wide range of vesicles and organelles. They play a role in many processes including budding of transport vesicles.ivision of organelles.ytokinesis and pathogen resistance. The minimal distinguishing architectural features that are common to all dynamins and are distinct from other GTPases are the structure of the large GTPase domain (300 amino acids) and the presence of two additional domains; the middle domain and the GTPase effector domain (GED).hich are involved in oligomerization and regulation of the GTPase activity. The GTPase domain contains the GTP-binding motifs that are needed for guanine-nucleotide binding and hydrolysis. The conservation of these motifs is absolute except for the the final motif in guanylate-binding proteins. The GTPase catalytic activity can be stimulated by oligomerisation of the protein.hich is mediated by interactions between the GTPase domain.he middle domain and the GED.
  IPR001401:Dynamin
IPR006884:Fzo_mitofusin 
Evalue:-125.113510131836 
Location:586-756IPR001401:Dynamin_N 
Evalue:-26.8239078521729 
Location:99-259
SequencesProtein: MFN2_HUMAN (757 aa)
mRNA: NM_014874
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK06030
  Level 3 annotation:
    
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 58 residues, 11962955-11963128Exon2: 50 residues, 11964613-11964758Exon3: 61 residues, 11971808-11971987Exon4: 47 residues, 11975198-11975334Exon5: 56 residues, 11978799-11978962Exon6: 43 residues, 11979940-11980065Exon7: 38 residues, 11981413-11981522Exon8: 38 residues, 11981631-11981739Exon9: 53 residues, 11984044-11984198Exon10: 24 residues, 11984412-11984480Exon11: 42 residues, 11984625-11984747Exon12: 44 residues, 11986635-11986762Exon13: 37 residues, 11987152-11987257Exon14: 36 residues, 11987468-11987571Exon15: 75 residues, 11988354-11988575Exon16: 54 residues, 11989181-11989337Exon17: 67 residues, 11989696-11989893Exon18: 47 residues, 11992235-11992370Exon19: 673 residues, 11994139-11996152Exon20: 2 residues, -Jump to MFN2_HUMAN  
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