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0MELPH_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionMelanophilin (exophilin-3) (synaptotagmin-like protein 2a) (slp homolog lacking c2 domains-a).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
SequencesProtein: MELPH_HUMAN (600 aa)
mRNA: NM_024101
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 51 residues, 238060668-238060819Exon2: 46 residues, 238066784-238066918Exon3: 76 residues, 238083955-238084177Exon4: 39 residues, 238084370-238084483Exon5: 38 residues, 238091920-238092030Exon6: 42 residues, 238093291-238093411Exon7: 70 residues, 238098982-238099187Exon8: 48 residues, 238100758-238100898Exon9: 30 residues, 238107945-238108029Exon10: 64 residues, 238113729-238113915Exon11: 54 residues, 238114183-238114339Exon12: 33 residues, 238115948-238116041Exon13: 28 residues, 238119987-238120065Exon14: 21 residues, 238122602-238122660Exon15: 35 residues, 238125718-238125819Exon16: 144 residues, 238126947-238127375Exon17: 2 residues, -Jump to MELPH_HUMAN  
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Loci Cluster (Details)Loci: 3224 238060668-238127375 ~-67K 22362(MLPH)(+)Loci: 4501 238147703-238164475 ~-17K 22365(RAB17)(-)Loci: 3223 237658822-237672226 ~-13K 22354(COPS8)(+)Link out to UCSC