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0MCR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNR3C2
DescriptionMineralocorticoid receptor (mr).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003707 steroid hormone receptor activity (TAS)
0003700 transcription factor activity (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences ().onnected via a linker region to a C-terminal ligand-binding domain. In addition.ertain nuclear hormone receptors have an N-terminal modulatory domain (). The ligand-binding domain acts in response to ligand binding.hich caused a conformational change in the receptor to induce a response.hereby acting as a molecular switch to turn on transcriptional activity . For example.fter binding of the glucocorticoid receptor to the corticosteroid ligand.he receptor is induced to perform functions ranging from nuclear translocation.ligomerisation.ofactor/kinase/transcription factor association.nd DNA binding . The ligand-binding domain is a flexible unit.here the binding of a ligand stabilises its conformation.hich in turn favours coactivator binding to modify receptor activity ; the coactivator can bind to the activator function 2 (AF2) site at the C-terminal end of the ligand-binding domain . The binding of different ligands can alter the conformation of the ligand-binding domain.hich ultimately affects the DNA-binding specificity of the DNA-binding domain. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components. This entry represents the C-terminal ligand-binding domain.
  IPR000536:Nuclear hormone receptor, ligand-binding
Steroid or nuclear hormone receptors (NRs) constitute an important super- family of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone.etinoids..5-dihydroxy-vitamin D3 and a variety of other ligands. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner . In addition to C-terminal ligand-binding domains.hese nuclear receptors contain a highly-conserved.-terminal zinc-finger that mediates specific binding to target DNA sequences.ermed ligand-responsive elements. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. NRs are extremely important in medical research. large number of them being implicated in diseases such as cancer.iabetes.ormone resistance syndromes.tc. While several NRs act as ligand-inducible transcription factors.any do not yet have a defined ligand and are accordingly termed "orphan" receptors. During the last decade.ore than 300 NRs have been described.any of which are orphans.hich cannot easily be named due to current nomenclature confusions in the literature. However. new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The vitamin D receptor (VDR) mediates the signal of 1-a.5-dihydroxyvitamin D3 by binding to vitamin D responsive elements - it functions either as a homodimer.r as a heterodimer of vitamin D and retinoid X receptor subunits. Deficiency of VDR causes type IIA rickets .
  IPR000324:Vitamin D receptor
Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences.onnected via a linker region to a C-terminal ligand-binding domain (). In addition.ertain nuclear hormone receptors have an N-terminal modulatory domain (). The DNA-binding domain can elicit either an activating or repressing effect by binding to specific regions of the DNA known as hormone-response elements . These response elements position the receptors.nd the complexes recruited by them.lose to the genes of which transcription is affected. The DNA-binding domains of nuclear receptors consist of two zinc-nucleated modules and a C-terminal extension.here residues in the first zinc module determine the specificity of the DNA recognition and residues in the second zinc module are involved in dimerisation. The DNA-binding domain is furthermore involved in several other functions including nuclear localization.nd interaction with transcription factors and co-activators . This entry represents the two zinc finger modules involved in DNA-binding.
  IPR001628:Nuclear hormone receptor, DNA-binding
Steroid or nuclear hormone receptors (4A nuclear receptor.Rs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone.etinoids..5-dihydroxy-vitamin D3 and a variety of other ligands . The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner . In addition to C-terminal ligand-binding domains.hese nuclear receptors contain a highly-conserved.-terminal zinc-finger that mediates specific binding to target DNA sequences.ermed ligand-responsive elements. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research. large number of them being implicated in diseases such as cancer.iabetes.ormone resistance syndromes.tc. While several NRs act as ligand-inducible transcription factors.any do not yet have a defined ligand and are accordingly termed orphan receptors. During the last decade.ore than 300 NRs have been described.any of which are orphans.hich cannot easily be named due to current nomenclature confusions in the literature. However. new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008946:Nuclear receptor, ligand-binding
IPR000536:Hormone_recep 
Evalue:-47.5686378479004 
Location:774-963IPR001628:zf-C4 
Evalue:-46.1938209533691 
Location:601-676IPR008946:Str_ncl_receptor 
Evalue:0 
Location:5-19IPR001969:ASP_PROTEASE 
Evalue:0 
Location:0-0
SequencesProtein: MCR_HUMAN (984 aa)
mRNA: NM_000901
Local Annotation
Synapse Ontology
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 911 residues, 149219369-149222100Exon2: 54 residues, 149254704-149254862Exon3: 45 residues, 149260758-149260889Exon4: 50 residues, 149293069-149293214Exon5: 119 residues, 149295151-149295502Exon6: 41 residues, 149335346-149335463Exon7: 48 residues, 149400579-149400719Exon8: 588 residues, 149575705-149577463Exon9: 73 residues, 149582760-149582973Exon10: 2 residues, -Jump to MCR_HUMAN  
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