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0MCLN1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMCOLN1
DescriptionMucolipin-1 (mucolipidin) (mg-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (NAS)
0005261 cation channel activity (NAS)
0006812 cation transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
The Gag polyprotein from retroviruses is processed by viral protease to produce the major structural proteins.ncluding the capsid protein. The newly formed capsid protein rearranges to form the capsid core particle that surrounds the viral genome of the mature virus. The capsid is composed of two domains.he N-terminal domain (NTD).hich contributes to viral core formation.nd the C-terminal domain (CTD).hich is required for capsid dimerisation.ag oligomerization and viral formation. The NTD is composed of a five-helix bundle .
  IPR008919:Retrovirus capsid, N-terminal core
IPR005821:Ion_trans 
Evalue:-2.44369745254517 
Location:356-517IPR008919:Retrov_capsid_N 
Evalue:0 
Location:12-62IPR008262:LIPASE_SER 
Evalue:0 
Location:104-113
SequencesProtein: MCLN1_HUMAN (580 aa)
mRNA: AJ293659 NM_020533
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentK04992
  Level 3 annotation:
    mucolipin 1
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 53 residues, 7493511-7493667Exon2: 70 residues, 7495846-7496052Exon3: 58 residues, 7497324-7497492Exon4: 57 residues, 7497646-7497812Exon5: 38 residues, 7498405-7498514Exon6: 34 residues, 7498749-7498846Exon7: 35 residues, 7499043-7499143Exon8: 37 residues, 7499482-7499589Exon9: 52 residues, 7499706-7499856Exon10: 36 residues, 7499986-7500088Exon11: 43 residues, 7500475-7500598Exon12: 74 residues, 7501171-7501387Exon13: 45 residues, 7504408-7504539Exon14: 74 residues, 7504644-7504861Exon15: 2 residues, -Jump to MCLN1_HUMANExon1: 38 residues, 7493556-7493667Exon2: 70 residues, 7495846-7496052Exon3: 58 residues, 7497324-7497492Exon4: 57 residues, 7497646-7497812Exon5: 149 residues, 7498405-7498846Exon6: 35 residues, 7499043-7499143Exon7: 37 residues, 7499482-7499589Exon8: 52 residues, 7499706-7499856Exon9: 36 residues, 7499986-7500088Exon10: 43 residues, 7500475-7500598Exon11: 74 residues, 7501171-7501387Exon12: 45 residues, 7504408-7504539Exon13: 77 residues, 7504644-7504871Exon14: 2 residues, -Jump to MCLN1_HUMAN  
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Loci Cluster (Details)Loci: 3084 7493511-7504871 ~-11K 17845(MCOLN1)(+)Loci: 3085 7608012-7618758 ~-11K 17854(STXBP2)(+)Loci: 4362 7897603-7914538 ~-17K 17882(TIMM44)(-)Loci: 3086 8361295-8374479 ~-13K 17895(RAB11B)(+)Loci: 4361 7067641-7245011 ~-177K 17833(INSR)(-)Link out to UCSC