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0MCH_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePMCH
DescriptionPro-mch precursor .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (NAS)
0030354 melanin-concentrating hormone activity (ISS)
0005102 receptor binding (ISS)
0007631 feeding behavior (ISS)
0007165 signal transduction (NAS)
0007283 spermatogenesis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Melanin-concentrating hormone (MCH) is a cyclic peptide originally identified in teleost fish . In fish.CH is released from the pituitary and causes lightening of skin pigment cells through pigment aggregation . In mammals.CH is predominantly expressed in the hypothalamus.nd functions as a neurotransmitter in the control of a range of functions. A major role of MCH is thought to be in the regulation of feeding: injection of MCH into rat brains stimulates feeding; expression of MCH is upregulated in the hypothalamus of obese and fasting mice; and mice lacking MCH are lean and eat less . MCH and alpha melanocyte-stimulating hormone (alpha-MSH) have antagonistic effects on a number of physiological functions. Alpha-MSH darkens pigmentation in fish and reduces feeding in mammals.hereas MCH increases feeding . MCH is derived from a pre-pro-hormone (pre-pro-MCH).hich contains 1-2 hormones other than MCH.epending on the species. In all species.he 17-19 C-terminal amino acids are cleaved to release MCH. In mammals.mino acids 132-144 encode the hormone neuropeptide EI (NEI).hilst in salmonids.he analagous region encodes neuropeptide EV (NEV).nd in other fish.he region determines MCH gene-related peptide (Mgrp) . A further peptide.nown as neuropeptide GE (NGE).s thought to be found in mammalian pre-pro-MCH upstream of NEI.ncoded by amino acids 110-129. NEI has been shown to enhance oxytocin and reduce arginine vasopressin secretion from rat pituitary . Two paralogues of MCH.nown as pro-MCH-like 1 and 2 genes (PMCHL1 and PMCHL2).hich arose recently in primate evolution.lso exist. At present.t is unclear whether the PMCHL genes are functional genes or inactive pseudogenes.
  IPR005456:Pre-pro melanin-concentrating hormone
IPR005456:Pro-MCH 
Evalue:-65.958610534668 
Location:80-165
SequencesProtein: MCH_HUMAN (165 aa)
mRNA: NM_002674
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 81 residues, 101114368-101114609Exon2: 68 residues, 101114880-101115079Exon3: 107 residues, 101115429-101115744Exon4: 2 residues, -Jump to MCH_HUMAN  
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Loci Cluster (Details)Loci: 4069 101313806-101398471 ~-85K 9551(IGF1)(-)Loci: 4068 101114368-101115744 ~-1K 9550(PMCH)(-)Link out to UCSC