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0MCCC2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMCCC2
DescriptionMethylcrotonoyl-coa carboxylase beta chain, mitochondrial precursor (ec 6.4.1.4) (3-methylcrotonyl-coa carboxylase 2) (mccase beta subunit) (3-methylcrotonyl-coa:carbon dioxide ligase beta subunit) (3- methylcrotonyl-coa carboxylase non-biotin-containing subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (NAS)
0004485 methylcrotonoyl-CoA carboxylase activity (NAS)
0006552 leucine catabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Members in this domain include biotin dependent carboxylases.The carboxyl transferase domain carries out the following reaction;transcarboxylation from biotin to an acceptor molecule. There aretwo recognised types of carboxyl transferase. One of them uses acyl-CoAand the other uses 2-oxo acid as the acceptor molecule of carbon dioxide. All of the members in this family utilise acyl-CoA as the acceptormolecule.
  IPR000022:Carboxyl transferase
IPR000022:Carboxyl_trans 
Evalue:-212.337249755859 
Location:69-561
SequencesProtein: MCCC2_HUMAN (563 aa)
mRNA: NM_022132
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01969
  Level 3 annotation:
    3-methylcrotonyl-CoA carboxylase beta subunit
  Level 2 annotation:
    Valine
     leucine and isoleucine degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 77 residues, 70918909-70919137Exon2: 24 residues, 70924508-70924575Exon3: 30 residues, 70927862-70927947Exon4: 36 residues, 70931241-70931343Exon5: 44 residues, 70934088-70934216Exon6: 39 residues, 70935938-70936051Exon7: 40 residues, 70958222-70958336Exon8: 23 residues, 70963703-70963768Exon9: 35 residues, 70966525-70966625Exon10: 34 residues, 70966733-70966829Exon11: 26 residues, 70972585-70972658Exon12: 27 residues, 70975401-70975478Exon13: 24 residues, 70977793-70977860Exon14: 54 residues, 70980679-70980836Exon15: 40 residues, 70981651-70981766Exon16: 30 residues, 70984251-70984337Exon17: 220 residues, 70988325-70988981Exon18: 2 residues, -Jump to MCCC2_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 77 residues, 1543972-1544200Exon2: 24 residues, 1549571-1549638Exon3: 30 residues, 1552925-1553010Exon4: 36 residues, 1556304-1556406Exon5: 44 residues, 1559151-1559279Exon6: 39 residues, 1561001-1561114Exon7: 40 residues, 1583285-1583399Exon8: 23 residues, 1588766-1588831Exon9: 35 residues, 1591588-1591688Exon10: 34 residues, 1591796-1591892Exon11: 26 residues, 1597648-1597721Exon12: 27 residues, 1600464-1600541Exon13: 24 residues, 1602856-1602923Exon14: 54 residues, 1605742-1605899Exon15: 40 residues, 1606714-1606829Exon16: 30 residues, 1609314-1609400Exon17: 220 residues, 1613388-1614044Exon18: 2 residues, -Jump to MCCC2_HUMAN  
Loci Cluster (Details)Loci: 3464 71050749-71052628 ~-2K 28983(CART)(+)Loci: 3465 71438890-71538608 ~-100K 28984(MAP1B)(+)Loci: 4717 71551111-71651809 ~-101K 28987(MRPS27)(-)Loci: 3463 70918909-70988981 ~-70K 28982(MCCC2)(+)Link out to UCSC  
Loci: 3517 1675812-1677691 ~-2K 30188(CART)(+)Loci: 3516 1543972-1614044 ~-70K 30187(MCCC2)(+)Link out to UCSC