SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0MARK3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMARK3
DescriptionMap/microtubule affinity-regulating kinase 3 (ec 2.7.1.37) (cdc25c- associated protein kinase 1) (ctak1) (c-tak1) (serine/threonine protein kinase p78) (ser/thr protein kinase par-1) (protein kinase stk10).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme .This domain is found in the C-terminal extremity of various serine/threonine-protein kinases from fungi.lants and animals.
  IPR001772:Kinase-associated, C-terminal
UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway.NA excision-repair.nd cell signaling via protein kinases . The human homologue of yeast Rad23A is one example of a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The solution structure of human Rad23A UBA(2) showed that the domain forms a compact three-helix bundle . Comparison of the structures of UBA(1) and UBA(2) reveals that both form very similar folds and have a conserved large hydrophobic surface patch which may be a common protein-interacting surface present in diverse UBA domains. Evidence that ubiquitin binds to UBA domains leads to the prediction that the hydrophobic surface patch of UBA domains interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin .
  IPR000449:Ubiquitin-associated
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-96.2757241303992 
Location:56-330IPR001772:KA1 
Evalue:-23.2076091766357 
Location:727-776IPR000449:UBA 
Evalue:-8.16749108729376 
Location:351-388
SequencesProtein: MARK3_HUMAN (776 aa)
mRNA: AF159295 AF387637 AF465413 NM_002376
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK00862
  Level 3 annotation:
    erythritol kinase
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 216 residues, 102921523-102922170Exon2: 66 residues, 102941165-102941357Exon3: 20 residues, 102964476-102964530Exon4: 18 residues, 102985008-102985057Exon5: 24 residues, 102988007-102988073Exon6: 25 residues, 102993231-102993302Exon7: 21 residues, 102998494-102998551Exon8: 81 residues, 103001646-103001883Exon9: 42 residues, 103002061-103002181Exon10: 35 residues, 103002432-103002532Exon11: 39 residues, 103003168-103003281Exon12: 53 residues, 103004122-103004276Exon13: 74 residues, 103011082-103011300Exon14: 36 residues, 103016476-103016580Exon15: 88 residues, 103027866-103028124Exon16: 317 residues, 103038971-103039917Exon17: 2 residues, -Jump to MARK3_HUMANExon1: 210 residues, 102921542-102922170Exon2: 66 residues, 102941165-102941357Exon3: 20 residues, 102964476-102964530Exon4: 18 residues, 102985008-102985057Exon5: 24 residues, 102988007-102988073Exon6: 25 residues, 102993231-102993302Exon7: 25 residues, 102994816-102994885Exon8: 21 residues, 102998494-102998551Exon9: 81 residues, 103001646-103001883Exon10: 42 residues, 103002061-103002181Exon11: 35 residues, 103002432-103002532Exon12: 39 residues, 103003168-103003281Exon13: 53 residues, 103004122-103004276Exon14: 74 residues, 103011082-103011300Exon15: 36 residues, 103016476-103016580Exon16: 88 residues, 103027866-103028124Exon17: 161 residues, 103038971-103039450Exon18: 2 residues, -Jump to MARK3_HUMANExon1: 188 residues, 102921609-102922170Exon2: 66 residues, 102941165-102941357Exon3: 20 residues, 102964476-102964530Exon4: 18 residues, 102985008-102985057Exon5: 25 residues, 102988007-102988076Exon6: 24 residues, 102993234-102993302Exon7: 21 residues, 102998494-102998551Exon8: 81 residues, 103001646-103001883Exon9: 42 residues, 103002061-103002181Exon10: 35 residues, 103002432-103002532Exon11: 39 residues, 103003168-103003281Exon12: 53 residues, 103004122-103004276Exon13: 74 residues, 103011082-103011300Exon14: 36 residues, 103016476-103016580Exon15: 88 residues, 103027866-103028124Exon16: 11 residues, 103034591-103034618Exon17: 17 residues, 103036245-103036290Exon18: 317 residues, 103038971-103039916Exon19: 2 residues, -Jump to MARK3_HUMANExon1: 24 residues, 102922101-102922170Exon2: 66 residues, 102941165-102941357Exon3: 20 residues, 102964476-102964530Exon4: 18 residues, 102985008-102985057Exon5: 24 residues, 102988007-102988073Exon6: 25 residues, 102993231-102993302Exon7: 21 residues, 102998494-102998551Exon8: 81 residues, 103001646-103001883Exon9: 42 residues, 103002061-103002181Exon10: 35 residues, 103002432-103002532Exon11: 39 residues, 103003168-103003281Exon12: 53 residues, 103004122-103004276Exon13: 74 residues, 103011082-103011300Exon14: 36 residues, 103016476-103016580Exon15: 88 residues, 103027866-103028124Exon16: 17 residues, 103036245-103036290Exon17: 123 residues, 103038971-103039334Exon18: 2 residues, -Jump to MARK3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2865 103165326-103247461 ~-82K 11833(KNS2)(+)Loci: 4154 103269841-103383555 ~-114K 11841(PPP1R13B)(-)Loci: 2864 102921523-103039917 ~-118K 11819(MARK3)(+)Link out to UCSC