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0MARE2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAPRE2
DescriptionMicrotubule-associated protein rp/eb family member 2 (apc-binding protein eb2) (end-binding protein 2) (eb2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008283 cell proliferation (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The human EB1 protein was originally discovered as a protein interacting with the C-terminus of the APC protein. This interaction is often disrupted in colon cancer.ue to deletions affecting the APC C-terminus. Several EB1 orthologues are also included in this family. The interaction between EB1 and APC has been shown to have a potent synergistic effect on microtubule polymerization. Neither of EB1 or APC alone has this effect. It is thought that EB1 targets APC to the + ends of microtubules.here APC promotes microtubule polymerization. This process is regulated by APC phosphorylation by Cdc2.hich disrupts APC-EB1 binding. Human EB1 protein can functionally substitute for the yeast EB1 homologue Mal3. In addition.al3 can substitute for human EB1 in promoting microtubule polymerization with APC.
  IPR004953:EB1
The calponin homology domain (also known as CH-domain) is a superfamily of actin-binding domains found in both cytoskeletal proteins and signal transduction proteins . It comprises the following groups of actin-binding domains:Actinin-type (including spectrin.imbrin.BP-280) (see ).Calponin-type (see ).A comprehensive review of proteins containing this type of actin-binding domains is given in .The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity . Most proteins have two copies of the CH domain.owever some proteins such as calponin and the human vav proto-oncogene () have only a single copy. The structure of an example CH-domain has recently been solved .
  IPR001715:Calponin-like actin-binding
IPR004953:EB1 
Evalue:-25.8860569000244 
Location:260-307IPR001715:CH 
Evalue:-13.3767509460449 
Location:58-159
SequencesProtein: MARE2_HUMAN (327 aa)
mRNA: NM_014268
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 79 residues, 30875388-30875623Exon2: 44 residues, 30904156-30904284Exon3: 50 residues, 30931407-30931553Exon4: 73 residues, 30935907-30936121Exon5: 48 residues, 30960909-30961049Exon6: 55 residues, 30965993-30966152Exon7: 521 residues, 30974256-30975813Exon8: 2 residues, -Jump to MARE2_HUMAN  
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