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0MAP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAP2
DescriptionMicrotubule-associated protein 2 (map 2) (map-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005875 microtubule associated complex (TAS)
0005198 structural molecule activity (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in the MAP2/Tau family of proteins which includes MAP2.AP4.au.nd their homologues. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats ().nd a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport .
  IPR013588:MAP2/Tau projection
Microtubules consist of tubulins as well as a group of additional proteinscollectively known as the Microtubule Associated Proteins (MAP). MAPs havebeen classified into two classes: high molecular weight MAPs and Tauprotein. The Tau proteins promote microtubule assembly and stabilizemicrotubules.The C-terminal region of these proteins contains three or four tandem repeatsof a conserved domain of about thirty amino acid residues which is implicatedin tubulin-binding and which seems to have a stiffening effect on microtubules.
  IPR001084:Tubulin-binding Tau protein
IPR013588:MAP2_projctn 
Evalue:-1e+125 
Location:377-1505IPR001084:Tubulin-binding 
Evalue:-15.8538722991943 
Location:1692-1722IPR001084:Tubulin-binding 
Evalue:-15.4948501586914 
Location:1660-1691IPR001084:Tubulin-binding 
Evalue:-13.7695512771606 
Location:1723-1754
SequencesProtein: MAP2_HUMAN (1827 aa)
mRNA: NM_002374 NM_031846 U89330
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 26 residues, 210152647-210152724Exon2: 23 residues, 210153004-210153069Exon3: 27 residues, 210198021-210198098Exon4: 99 residues, 210226110-210226401Exon5: 40 residues, 210251540-210251654Exon6: 28 residues, 210253718-210253796Exon7: 1244 residues, 210265593-210269319Exon8: 71 residues, 210269510-210269717Exon9: 47 residues, 210269885-210270020Exon10: 22 residues, 210273245-210273307Exon11: 51 residues, 210278548-210278696Exon12: 115 residues, 210282882-210283223Exon13: 33 residues, 210296563-210296656Exon14: 29 residues, 210298677-210298759Exon15: 39 residues, 210302818-210302931Exon16: 285 residues, 210303150-210303999Exon17: 58 residues, 210304053-210304223Exon18: 2 residues, -Jump to MAP2_HUMANExon1: 26 residues, 210152647-210152724Exon2: 23 residues, 210153004-210153069Exon3: 27 residues, 210198021-210198098Exon4: 99 residues, 210226110-210226401Exon5: 40 residues, 210251540-210251654Exon6: 28 residues, 210253718-210253796Exon7: 1244 residues, 210265593-210269319Exon8: 71 residues, 210269510-210269717Exon9: 47 residues, 210269885-210270020Exon10: 22 residues, 210273245-210273307Exon11: 51 residues, 210278548-210278696Exon12: 115 residues, 210282882-210283223Exon13: 29 residues, 210298677-210298759Exon14: 39 residues, 210302818-210302931Exon15: 285 residues, 210303150-210303999Exon16: 58 residues, 210304053-210304223Exon17: 2 residues, -Jump to MAP2_HUMANExon1: 88 residues, 210226139-210226401Exon2: 40 residues, 210251540-210251654Exon3: 28 residues, 210253718-210253796Exon4: 1240 residues, 210265605-210269319Exon5: 71 residues, 210269510-210269717Exon6: 47 residues, 210269885-210270020Exon7: 22 residues, 210273245-210273307Exon8: 51 residues, 210278548-210278696Exon9: 115 residues, 210282882-210283223Exon10: 29 residues, 210298677-210298759Exon11: 39 residues, 210302818-210302931Exon12: 111 residues, 210303150-210303478Exon13: 2 residues, -Jump to MAP2_HUMAN  
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