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0MAOM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameME2
DescriptionNad-dependent malic enzyme, mitochondrial precursor (ec 1.1.1.38) (nad-me) (malic enzyme 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005489 electron transporter activity (TAS)
0004471 malate dehydrogenase (decarboxylating) acti... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate . reaction important in a number of metabolic pathways - e.g. carbon dioxide released from the reaction may be used in sugar production during the Calvin cycle of photosynthesis . There are 3 forms of the enzyme : an NAD-dependent form that decarboxylates oxaloacetate; an NAD-dependent form that does not decarboxylate oxalo-acetate; and an NADPH-dependent form . Other proteins known to be similar to malic enzymes are the Escherichia coli scfA protein; an enzyme from Zea mays (Maize).ormerly thought to be cinnamyl-alcohol dehydrogenase ; and the hypothetical Saccharomyces cerevisiae protein YKL029c.Studies on the duck liver malic enzyme reveals that it can be alkylated by bromopyruvate.esulting in the loss of oxidative decarboxylation and the subsequent enhancement of pyruvate reductase activity . The alkylated form is able to bind NADPH but not L-malate.ndicating impaired substrate-or divalent metal ion-binding in the active site . Sequence analysis has highlighted a cysteine residue as the point of alkylation.uggesting that it may play an important role in the activity of the enzyme .lthough it is absent in the sequences from some species.There are three well conserved regions in the enzyme sequences. Two of them seem to be involved in the binding NAD or NADP. The significance of the third one.ocated in the central part of the enzymes.s not yet known.
  IPR012302:Malic enzyme, NAD-binding
Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate . reaction important in a number of metabolic pathways - e.g. carbon dioxide released from the reaction may be used in sugar production during the Calvin cycle of photosynthesis . There are 3 forms of the enzyme : an NAD-dependent form that decarboxylates oxaloacetate; an NAD-dependent form that does not decarboxylate oxalo-acetate; and an NADPH-dependent form . Other proteins known to be similar to malic enzymes are the Escherichia coli scfA protein; an enzyme from Zea mays (Maize).ormerly thought to be cinnamyl-alcohol dehydrogenase ; and the hypothetical Saccharomyces cerevisiae protein YKL029c.Studies on the duck liver malic enzyme reveals that it can be alkylated by bromopyruvate.esulting in the loss of oxidative decarboxylation and the subsequent enhancement of pyruvate reductase activity . The alkylated form is able to bind NADPH but not L-malate.ndicating impaired substrate-or divalent metal ion-binding in the active site . Sequence analysis has highlighted a cysteine residue as the point of alkylation.uggesting that it may play an important role in the activity of the enzyme .lthough it is absent in the sequences from some species.There are three well conserved regions in the enzyme sequences. Two of them seem to be involved in the binding NAD or NADP. The significance of the third one.ocated in the central part of the enzymes.s not yet known.
  IPR012301:Malic enzyme, N-terminal
Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate . reaction important in a number of metabolic pathways - e.g. carbon dioxide released from the reaction may be used in sugar production during the Calvin cycle of photosynthesis . There are 3 forms of the enzyme : an NAD-dependent form that decarboxylates oxaloacetate; an NAD-dependent form that does not decarboxylate oxalo-acetate; and an NADPH-dependent form . Other proteins known to be similar to malic enzymes are the Escherichia coli scfA protein; an enzyme from Zea mays (Maize).ormerly thought to be cinnamyl-alcohol dehydrogenase ; and the hypothetical Saccharomyces cerevisiae protein YKL029c.Studies on the duck liver malic enzyme reveals that it can be alkylated by bromopyruvate.esulting in the loss of oxidative decarboxylation and the subsequent enhancement of pyruvate reductase activity . The alkylated form is able to bind NADPH but not L-malate.ndicating impaired substrate-or divalent metal ion-binding in the active site . Sequence analysis has highlighted a cysteine residue as the point of alkylation.uggesting that it may play an important role in the activity of the enzyme .lthough it is absent in the sequences from some species.There are three well conserved regions in the enzyme sequences. Two of them seem to be involved in the binding NAD or NADP. The significance of the third one.ocated in the central part of the enzymes.s not yet known.
  IPR001891:Malic oxidoreductase
IPR012302:Malic_M 
Evalue:-135 
Location:280-535IPR012301:malic 
Evalue:-127.744728088379 
Location:89-278
SequencesProtein: MAOM_HUMAN (584 aa)
mRNA: NM_002396
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00027
  Level 3 annotation:
    malate dehydrogenase (oxaloacetate-decarboxylating)
  Level 2 annotation:
    Pyruvate metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 82 residues, 46659432-46659676Exon2: 42 residues, 46676176-46676296Exon3: 46 residues, 46688430-46688564Exon4: 52 residues, 46693168-46693318Exon5: 27 residues, 46696535-46696611Exon6: 56 residues, 46697714-46697876Exon7: 36 residues, 46698477-46698581Exon8: 38 residues, 46700823-46700933Exon9: 34 residues, 46701028-46701126Exon10: 40 residues, 46701441-46701555Exon11: 40 residues, 46704465-46704580Exon12: 49 residues, 46706123-46706266Exon13: 36 residues, 46712625-46712728Exon14: 25 residues, 46719937-46720008Exon15: 35 residues, 46720655-46720754Exon16: 292 residues, 46727384-46728256Exon17: 2 residues, -Jump to MAOM_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3067 46748384-46768487 ~-20K 17312(ELAC1)(+)Loci: 3066 46659432-46728256 ~-69K 17310(ME2)(+)Link out to UCSC