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0MAN1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLEMD3
DescriptionInner nuclear membrane protein man1 (lem domain containing protein 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005639 integral to nuclear inner membrane (TAS)
0005624 membrane fraction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The LEM domain is found in nuclear membrane-associated proteins.ncluding lamino-associated polypeptide 2 and emerin . Defects in the emerin gene are a cause of Emery-Dreifuss muscular dystrophy.n X-linked disorder characterised by early contractures.uscle wasting.eakness and cardiomyopathy.
  IPR003887:Lamino-associated polypeptide 2/emerin
The LEM domain is a ~40-residue motif found in nuclearmembrane-associated proteins.ncluding lamino-associated polypeptide 2(LAP2).merin.AN1.tefin and Lem-3 . Defectsin the emerin gene are a cause of Emery-Dreifuss muscular dystrophy.nX-linked disorder characterised by early contractures.uscle wasting.eakness and cardiomyopathy. The N-terminal LEM domain in emerin mediatesbinding to BAF (barrier-to-autointegration factor).The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011015:LEM-like fold
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
The LEM domain is a ~40-residue motif found in nuclearmembrane-associated proteins.ncluding lamino-associated polypeptide 2(LAP2).merin.AN1.tefin and Lem-3 . Defectsin the emerin gene are a cause of Emery-Dreifuss muscular dystrophy.nX-linked disorder characterised by early contractures.uscle wasting.eakness and cardiomyopathy. The N-terminal LEM domain in emerin mediatesbinding to BAF (barrier-to-autointegration factor).
  IPR013142:LEM-like region
IPR003887:LEM 
Evalue:-22.6777801513672 
Location:6-49IPR012677:Nucl_bd_a/b_plat 
Evalue:0 
Location:783-867
SequencesProtein: MAN1_HUMAN (911 aa)
mRNA: NM_014319
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 510 residues, 63849637-63851165Exon2: 14 residues, 63890972-63891010Exon3: 24 residues, 63896023-63896090Exon4: 24 residues, 63898598-63898666Exon5: 28 residues, 63918548-63918628Exon6: 50 residues, 63918715-63918861Exon7: 36 residues, 63919975-63920077Exon8: 36 residues, 63920182-63920285Exon9: 61 residues, 63920955-63921134Exon10: 29 residues, 63923434-63923516Exon11: 37 residues, 63925715-63925821Exon12: 28 residues, 63925907-63925986Exon13: 724 residues, 63926208-63928374Exon14: 2 residues, -Jump to MAN1_HUMAN  
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