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0MAL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAL
DescriptionMyelin and lymphocyte protein (t-lymphocyte maturation-associated protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016324 apical plasma membrane (TAS)
0005783 endoplasmic reticulum (IDA)
0005768 endosome (TAS)
0005626 insoluble fraction (TAS)
0005887 integral to plasma membrane (TAS)
0045121 lipid raft (IDA)
0005624 membrane fraction (TAS)
0016505 apoptotic protease activator activity (NAS)
0015267 channel or pore class transporter activity (TAS)
0008289 lipid binding (TAS)
0019911 structural constituent of myelin sheath (IDA)
0045176 apical protein localization (TAS)
0030154 cell differentiation (TAS)
0007417 central nervous system development (TAS)
0007516 hemocyte development (TAS)
0006917 induction of apoptosis (NAS)
0001766 lipid raft polarization (TAS)
0042552 myelination (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
MARVEL domain is often found in lipid-associating proteins - such as Occludin and MAL family proteins . It may be part of the machinery of membrane apposition events.uch as transport vesicle biogenesis.
  IPR008253:Marvel
Myelin is a product of myelinating cells: Schawnn cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS). The processes of these myelinating cells wrap around axon segments to form a sheath. This sheath possesses insulating properties.llowing rapid propagation of action potentials (the electrical signal propagated by nerve cells) between the myelinating cell intervening nodes. Without myelin insulation.xons would need a 10-30-fold increase in diameter to achieve comparable conduction velocities. At the onset of myelination.uring development.arge amounts of myelin-specific lipids and proteins are synthesised and transported to the developing myelin sheath. The major protein component of PNS and CNS myelin differs between the 2 nervous systems. However.ome of the minor protein components.ncluding the 4 transmembrane (TM)-domain-containing myelin and lymphocyte protein (MAL).re found in both systems. Outside the nervous system.AL is also found in T-cells and some epithelial cells (e.g..idney.tomach and thyroid) . Glycosphingolipids are enriched in both epithelial cells and myelin.nd are believed to decrease the permeability of lipid membranes to small molecules and increase the ability for membrane curvature. MAL co-purifies with glycosphingolipids in detergent-insoluble domains.uggesting a possible interaction. In Madin Darby Canine Kidney (MDCK) cells.AL is found mainly in transport vesicles.nd recent studies suggest that MAL is required for efficient vesicular transport of proteins across apical cell membranes . In myelinating cells.AL appears to play a similar role.nteracting with glycosphingolipids to decrease membrane permeability; however.ere this property most likely manifests itself as an improved insulating ability of the myelin . In lymphocytes.owever.AL appears to act as a TM-linker protein in T-cell signal transduction.inking the cell surface glycosyl phosphatidylinositol anchored protein CD59 to the intracellular tyrosine kinase Lck .
  IPR013295:Myelin and lymphocyte (MAL)
IPR008253:MARVEL 
Evalue:-36.9208183288574 
Location:18-151
SequencesProtein: MAL_HUMAN (153 aa)
mRNA: NM_002371
Local Annotation
Synapse Ontology
supporting cells of the nervous system. Glial cells in the brain and spinal cord far outnumber nerve cells. They not only provide physical support, but also respond to injury, regulate the chemical composition surrounding cells, participate in the blood-brain and blood-spinal-cord barriers, form the myelin insulation of nervous pathways, help guide neuronal migration during development, and exchange metabolites with neurons. They may also produce substances that help and hinder regeneration in the spinal cord. The major types of glial cells in the CNS are astrocytes, oligodendrocytes, and microglia.
sdb:0008 Glia  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 51 residues, 95055205-95055357Exon2: 58 residues, 95077430-95077598Exon3: 44 residues, 95079052-95079178Exon4: 205 residues, 95082852-95083462Exon5: 2 residues, -Jump to MAL_HUMAN  
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