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0MAGI1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAGI1
DescriptionMembrane associated guanylate kinase, ww and pdz domain containing protein 1 (bai1-associated protein 1) (bap-1) (membrane associated guanylate kinase inverted-1) (magi-1) (atrophin-1-interacting protein 3) (aip3) (ww domain-containing protein 3) (wwp3) (trinucleotide repeat-containing gene 19 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005911 intercellular junction (TAS)
0005886 plasma membrane (TAS)
0008022 protein C-terminus binding (TAS)
0007155 cell adhesion (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)
0006461 protein complex assembly (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry represents a domain found in guanylate kinase () and in L-type calcium channel.Guanylate kinase () (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP.It is essential for recycling GMP and indirectly.GMP. In prokaryotes (such as Escherichia coli).ower eukaryotes(such as yeast) and in vertebrates.K is a highly conserved monomeric protein of about 200 amino acids. GKhas been shown to be structurally similar to protein A57R (or SalG2R)from various strains of Vaccinia virus. L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel.ince they form the drug binding domain. Other properties.uch as gating voltage-dependence. protein modulation and kinase susceptibility.re influenced by alpha-2.elta and beta subunits.
  IPR008145:Guanylate kinase/L-type calcium channel region
Synonym(s): Rsp5 or WWP domainThe WW domain is a short conserved region in a number ofunrelated proteins.hich folds as a stable.riple stranded beta-sheet.This short domain of approximately 40 amino acids.ay be repeated up to four times in some proteins . The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date.s well as that of aconserved Pro. The WW domain binds to proteins withparticular proline-motifs.AP]-P-P-[AP]-Y.nd/or phosphoserine- phosphothreonine-containing motifs . It is frequently associated with other domains typical for proteins insignal transduction processes.A large variety of proteins containing the WW domain are known. These include; dystrophin. multidomain cytoskeletal protein; utrophin. dystrophin-like protein of unknownfunction; vertebrate YAP protein.ubstrate of an unknown serine kinase; mouse NEDD-4.nvolved in the embryonic development and differentiation of the central nervous system;yeast RSP5.imilar to NEDD-4 in its molecular organization; rat FE65. transcription-factor activator expressed preferentially in liver; tobacco DB10 proteinand others.
  IPR001202:WW/Rsp5/WWP
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
Guanylate kinase () (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP.It is essential for recycling GMP and indirectly.GMP. In prokaryotes (such as Escherichia coli).ower eukaryotes(such as yeast) and in vertebrates.K is a highly conserved monomeric protein of about 200 amino acids. GKhas been shown to be structurally similar to protein A57R (or SalG2R)from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain.n SH3 domain as well as a C-terminal GK-likedomain.re collectively termed MAGUKs (membrane-associated guanylate kinase homologs) .ndinclude Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junctionprotein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail ofNMDA receptor subunits (SAP90/PSD-95.HAPSYN-110/PSD-93.AP97/DLG1 and SAP102); vertebrate 55 kD erythrocytemembrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There isan ATP-binding site (P-loop) in the N-terminal section of GK.hich is not conserved in the GK-like domain ofthe above proteins. However these proteins retain the residues known.n GK.o be involved in the binding ofGMP.
  IPR008144:Guanylate kinase
IPR008145:GuKc 
Evalue:-44.1870866433571 
Location:111-295IPR001478:PDZ 
Evalue:-22.6382721639824 
Location:1007-1094IPR001478:PDZ 
Evalue:-19.7958800173441 
Location:1160-1234IPR001478:PDZ 
Evalue:-18.3187587626244 
Location:849-925IPR001478:PDZ 
Evalue:-17.4202164033832 
Location:480-556IPR001478:PDZ 
Evalue:-14.6197887582884 
Location:651-723IPR001202:WW 
Evalue:-12.6382722854614 
Location:302-331IPR001202:WW 
Evalue:-9.92081832885742 
Location:361-390IPR001478:PDZ 
Evalue:-1.82390874094432 
Location:26-105
SequencesProtein: MAGI1_HUMAN (1491 aa)
mRNA: NM_015520
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK05631
  Level 3 annotation:
    atrophin-1 interacting protein 3 (BAI1-associated protein 1)
  Level 2 annotation:
    CAM ligands
    Tight junction
    Dentatorubropallidoluysian atrophy (DRPLA)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 968 residues, 65314946-65317847Exon2: 31 residues, 65319778-65319867Exon3: 48 residues, 65321913-65322052Exon4: 50 residues, 65324179-65324323Exon5: 22 residues, 65325379-65325440Exon6: 33 residues, 65325567-65325661Exon7: 69 residues, 65336459-65336660Exon8: 100 residues, 65339975-65340269Exon9: 66 residues, 65342591-65342784Exon10: 32 residues, 65344246-65344338Exon11: 30 residues, 65347857-65347941Exon12: 74 residues, 65351856-65352073Exon13: 12 residues, 65362153-65362185Exon14: 209 residues, 65390234-65390855Exon15: 63 residues, 65391413-65391596Exon16: 33 residues, 65397869-65397962Exon17: 46 residues, 65400593-65400727Exon18: 21 residues, 65403506-65403564Exon19: 14 residues, 65408736-65408772Exon20: 29 residues, 65413972-65414055Exon21: 69 residues, 65430997-65431199Exon22: 71 residues, 65439306-65439513Exon23: 42 residues, 65454226-65454346Exon24: 41 residues, 65582686-65582803Exon25: 281 residues, 65998710-65999549Exon26: 2 residues, -Jump to MAGI1_HUMAN