SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0M4K3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAP4K3
DescriptionMitogen-activated protein kinase kinase kinase kinase 3 (ec 2.7.1.37) (mapk/erk kinase kinase kinase 3) (mek kinase kinase 3) (mekkk 3) (germinal center kinase-related protein kinase) (glk).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005524 ATP binding (IDA)
0004674 protein serine/threonine kinase activity (IDA)
0007254 JNK cascade (TAS)
0006468 protein amino acid phosphorylation (IDA)
0007243 protein kinase cascade (IDA)
0006950 response to stress (IDA)

Warning: fopen(/home/kongl/syndb/www/temp/915978666.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Based on sequence similarities a domain of homology has been identified in the following proteins :Citron and Citron kinase. These two proteins interact with the GTP-bound forms of the small GTPases Rho and Rac but not with Cdc42.Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCKalpha). This serine/threonine kinase interacts with the GTP-bound form of the small GTPase Cdc42 and to a lesser extent with that of Rac.NCK Interacting Kinase (NIK). serine/threonine protein kinase.ROM-1 and ROM-2.rom yeast. These proteins are GDP/GTP exchange proteins (GEPs) for the small GTP binding protein Rho1.This domain.alled the citron homology domain.s often found after cysteine rich and pleckstrin homology (PH) domains at the C-terminal end of the proteins . It acts as a regulatory domain and could be involved in macromolecular interactions .
  IPR001180:Citron-like
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR001180:CNH 
Evalue:-115.481486060122 
Location:561-874IPR002290:S_TKc 
Evalue:-94.9586073148418 
Location:16-273IPR008271:PROTEIN_KINASE_ST 
Evalue:0 
Location:0-0
SequencesProtein: M4K3_HUMAN (894 aa)
mRNA: NM_003618
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK04406
  Level 3 annotation:
    mitogen-activated protein kinase kinase kinase kinase 3
  Level 2 annotation:
    MAPK signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 475 residues, 39329926-39331350Exon2: 20 residues, 39332474-39332530Exon3: 25 residues, 39335094-39335165Exon4: 33 residues, 39338992-39339085Exon5: 25 residues, 39339163-39339232Exon6: 59 residues, 39341250-39341422Exon7: 36 residues, 39345847-39345951Exon8: 21 residues, 39347833-39347892Exon9: 41 residues, 39352927-39353045Exon10: 22 residues, 39353126-39353187Exon11: 28 residues, 39359051-39359131Exon12: 30 residues, 39360916-39361001Exon13: 16 residues, 39363157-39363199Exon14: 39 residues, 39367496-39367609Exon15: 55 residues, 39368765-39368925Exon16: 16 residues, 39370936-39370979Exon17: 20 residues, 39373417-39373471Exon18: 15 residues, 39373874-39373913Exon19: 21 residues, 39380387-39380446Exon20: 23 residues, 39388587-39388650Exon21: 21 residues, 39390105-39390164Exon22: 28 residues, 39395954-39396033Exon23: 39 residues, 39406162-39406273Exon24: 29 residues, 39406374-39406456Exon25: 23 residues, 39406543-39406606Exon26: 46 residues, 39406790-39406922Exon27: 26 residues, 39412561-39412634Exon28: 16 residues, 39414176-39414219Exon29: 18 residues, 39417564-39417612Exon30: 20 residues, 39418170-39418226Exon31: 23 residues, 39424032-39424097Exon32: 32 residues, 39436893-39436984Exon33: 21 residues, 39458710-39458768Exon34: 64 residues, 39517536-39517723Exon35: 2 residues, -Jump to M4K3_HUMAN  
Tune and view alternative isoforms