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0M3K8_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAP3K8
DescriptionMitogen-activated protein kinase kinase kinase 8 (ec 2.7.1.37) (cot proto-oncogene serine/threonine-protein kinase) (c-cot) (cancer osaka thyroid oncogene).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005829 cytosol (TAS)
0005515 protein binding (IPI)
0004674 protein serine/threonine kinase activity (TAS)
0006468 protein amino acid phosphorylation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-49.7447280883789 
Location:146-388IPR000719:PROTEIN_KINASE_ATP 
Evalue:0 
Location:0-0
SequencesProtein: M3K8_HUMAN (467 aa)
mRNA: NM_005204
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK04415
  Level 3 annotation:
    mitogen-activated protein kinase kinase kinase 8
  Level 2 annotation:
    MAPK signaling pathway
    T cell receptor signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 148 residues, 30762871-30763313Exon2: 79 residues, 30766110-30766341Exon3: 121 residues, 30767850-30768209Exon4: 58 residues, 30776716-30776884Exon5: 89 residues, 30779192-30779454Exon6: 37 residues, 30780572-30780679Exon7: 53 residues, 30787018-30787171Exon8: 84 residues, 30788189-30788436Exon9: 377 residues, 30789640-30790767Exon10: 2 residues, -Jump to M3K8_HUMAN  
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Loci Cluster (Details)Loci: 2610 30762871-30790767 ~-28K 4659(MAP3K8)(+)Loci: 3883 30343389-30376777 ~-33K 4654(-)Link out to UCSC