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0M3K13_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionMitogen-activated protein kinase kinase kinase 13 (ec (mixed lineage kinase) (mlk) (leucine zipper-bearing kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005624 membrane fraction (IDA)
0004709 MAP kinase kinase kinase activity (IDA)
0005515 protein binding (IPI)
0042803 protein homodimerization activity (IDA)
0019901 protein kinase binding (ISS)
0004674 protein serine/threonine kinase activity (IDA)
0000186 activation of MAPKK activity (IDA)
0051092 activation of NF-kappaB transcription factor (IDA)
0046777 autophosphorylation (IDA)
0007254 JNK cascade (IDA)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases comprise a large family of enzymes that mediate the response of eukaryotic cells to external stimuli by phosphorylation of hydroxyamino acids. The enzymes fall into two broad classes.haracterised with respect to substrate specificity: serine/threonine specific and tyrosine specific . Tyrosine phosphorylating activity was originally detected in two viral transforming proteins .ut many retroviral transforming proteins and their cellular counterparts have since been shown to possess such activity. The growth factor receptors.hich are activated by ligand binding.nd theinsulin-related peptide also family members.
  IPR001245:Tyrosine protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
SequencesProtein: M3K13_HUMAN (966 aa)
mRNA: NM_004721
Local Annotation
Synapse Ontology
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04422
  Level 3 annotation:
    mitogen-activated protein kinase kinase kinase 13
  Level 2 annotation:
    MAPK signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 63 residues, 186563663-186563850Exon2: 188 residues, 186628978-186629538Exon3: 63 residues, 186637928-186638112Exon4: 66 residues, 186643926-186644118Exon5: 55 residues, 186648270-186648429Exon6: 55 residues, 186650381-186650540Exon7: 38 residues, 186651768-186651877Exon8: 38 residues, 186664031-186664141Exon9: 41 residues, 186666228-186666345Exon10: 48 residues, 186667307-186667445Exon11: 264 residues, 186673456-186674243Exon12: 25 residues, 186677807-186677878Exon13: 101 residues, 186680713-186681011Exon14: 162 residues, 186682836-186683318Exon15: 2 residues, -Jump to M3K13_HUMAN  
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Loci Cluster (Details)Loci: 3392 186563663-186683318 ~-120K 26969(MAP3K13)(+)Loci: 4651 186391107-186454531 ~-63K 26968(EHHADH)(-)Link out to UCSC