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0LPP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPAP2A
DescriptionLipid phosphate phosphohydrolase 1 (ec 3.1.3.4) (phosphatidic acid phosphatase 2a) (phosphatidate phosphohydrolase type 2a) (pap2a) (pap- 2a) (pap2-alpha).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (NAS)
0005624 membrane fraction (IDA)
0005886 plasma membrane (TAS)
0008195 phosphatidate phosphatase activity (IDA)
0004721 phosphoprotein phosphatase activity (TAS)
0030521 androgen receptor signaling pathway (NAS)
0008354 germ cell migration (TAS)
0008285 negative regulation of cell proliferation (NAS)
0046839 phospholipid dephosphorylation (TAS)
0007205 protein kinase C activation (TAS)
0019216 regulation of lipid metabolism (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family of enzymes includes phosphatidylglycerophosphatase B from Escherichia coli and other bacteria.ype 2 phosphatidic acidphosphatase (PAP2) as well as other phosphoesterases. Other proteins that contain this domain include a bacitracin transport permease from Bacillus licheniformis and a glucose-6-phosphatase from rat.
  IPR000326:Phosphoesterase, PA-phosphatase related
The vanadium-dependent haloperoxidases exclusively catalyse the oxidation of halides. Vanadium-dependent haloperoxidase has an almost all-helical structure.ith two four-helix bundles and only three small beta-sheets. The holoenzyme contains trigonal-bipyramidal coordinated vanadium atoms at its two active centres. The enzyme active sites of the vanadium haloperoxidases have shown some conservation with a completely different set of enzymes.he acid phosphatases. This sub-group of acid phosphatases are histidine phosphatase.sing histidine for the nucleophilic attack in the first step of the reaction . Amino acid residues involved in binding phosphate/vanadate are conserved between the two families.upporting a proposal that vanadium passes through a tetrahedral intermediate during the reaction mechanism.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008934:Acid phosphatase/vanadium-dependent haloperoxidase
IPR000326:PAP2 
Evalue:-52.3767509460449 
Location:101-251
SequencesProtein: LPP1_HUMAN (284 aa)
mRNA: NM_003711
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK01080
  Level 3 annotation:
    phosphatidate phosphatase
  Level 2 annotation:
    Glycerolipid metabolism
    Glycerophospholipid metabolism
    Glycosphingolipid metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 160 residues, 54756441-54756919Exon2: 61 residues, 54757447-54757624Exon3: 21 residues, 54773435-54773493Exon4: 95 residues, 54799453-54799734Exon5: 52 residues, 54806883-54807035Exon6: 160 residues, 54866156-54866630Exon7: 2 residues, -Jump to LPP1_HUMAN  
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