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0LPHN1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLPHN1
DescriptionLatrophilin-1 precursor (calcium-independent alpha-latrotoxin receptor 1) (lectomedin-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.Latrophilins are a family of secretin-like GPCRs that can be subdividedinto 3 subtypes: LPH1.PH2 and LPH3. LPH1 is a brain-specific calciumindependent receptor of alpha-latrotoxin (LTX). neurotoxin. It is theaffinity of this form of the receptor for LTX that gives the family its name. LPH2 and LPH3.hilst sharing extensive sequence similarity to LPH1.o not bind LTX. LPH2 is distributed throughout most tissues.hereas LPH3 is also brain-specific . The endogenous ligand(s) for these receptors are at present unknown. Binding of LTX to LPH1 stimulates exocytosis and thesubsequent release of large amounts of neurotransmitters from neuronal andendocrine cells. The latrophilins possess up to 7 sites of alternative splicing; the resulting number of possible splice variants leads to a highly variable family of proteins.
  IPR003924:Latrophilin receptor
InterPro domains unassigned to SynO:
Latrophilin is a member of the secretin family of G protein-coupled receptors. Alpha-Latrotoxin (LTX) stimulates massive exocytosis of synaptic vesicles and may help to elucidate the mechanism of regulation of neurosecretion. Latrophilin is the synaptic Ca2+-independent LTX receptor. The extracellular domain of latrophilin is homologous to olfactomedin (see ). soluble neuronal protein thought to participate in odorant binding. Latrophilin may bind unidentified endogenous ligands and transduce signals into nerve terminals.hus implicating G proteins in the control of synaptic vesicle exocytosis .
  IPR003334:Latrophilin, C-terminal
The olfactomedin-domain was first identified in olfactomedin.n extracellular matrix protein of the olfactory neuroepithelium . Members of this extracellular domain-family have since been shown to be present in several metazoan proteins.uch as latrophilins.yocilins.ptimedins and noelins.he latter being involved in the generation of neural crest cells. Myocilin is of considerable interest.s mutations in its olfactomedin-domain can lead to glaucoma . The olfactomedin-domains in myocilin and optimedin are essential for the interaction between these two proteins .
  IPR003112:Olfactomedin-like
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.
  IPR000832:GPCR, family 2, secretin-like
This domain has been termed the GPS domain (for GPCR proteolytic site).ecause it contains a cleavage site in latrophilin . However this region in latrophilin is found in many otherwise unrelated cell surface receptors . There is no evidence currently that this domain provides a cleavage site in any of the other receptors. However the peptide bond that is cleaved in latrophilin is between Leu and Thr residues that are conserved in some of the other receptors GPS domains are about 50 residues long and contain either 2 or 4 cysteine residues that are likely to form disulphide bridges. Based on conservation of these cysteines the following pairing can be predicted.
  IPR000203:GPS
This domain is found in the extracellular part of some hormone receptors including the calcitonin receptor; corticotropin releasing factor receptor 1; diuretic hormone receptor; glucagon-like peptide 1 receptor; and parathyroid hormone peptide receptor.
  IPR001879:Hormone receptor, extracellular
The D-galactoside binding lectin purified from sea urchin (Anthocidaris crassispina) eggs exists as a disulphide-linked homodimer of two subunits; the dimeric form is essential for hemagglutination activity . The sea urchin egg lectin (SUEL) forms a new class of lectins. Although SUEL was first isolated as a D-galactoside binding lectin it was latter shown that it bind to L-rhamnose preferentially . L-rhamnose and D-galactose share the same hydroxyl group orientation at C2 and C4 of the pyranose ring structure. A cysteine-rich domain homologous to the SUEL protein has been identified in the following proteins :Plant beta-galactosidases () (lactases).Mammalian latrophilin.he calcium independent receptor of alpha-latrotoxin (CIRL). The galactose-binding lectin domain is not required for alpha-latratoxin binding .Human lectomedin-1.Rhamnose-binding lectin (SAL) from catfish (Parasilurus asotus) eggs. This protein is composed of three tandem repeat domains homologous to the SUEL lectin domain. All cysteine positions of each domain are completely conserved .The hypothetical B0457.1.32A7.3A and F32A7.3B proteins from Caenorhabditis elegans.The human KIAA0821 protein.
  IPR000922:D-galactoside/L-rhamnose binding SUEL lectin
IPR003334:Latrophilin 
Evalue:-253.88606262207 
Location:1114-1474IPR003112:OLF 
Evalue:-152.853866577148 
Location:142-398IPR000832:7tm_2 
Evalue:-103.22184753418 
Location:857-1104IPR000922:Gal_Lectin 
Evalue:-46 
Location:48-128IPR000203:GPS 
Evalue:-27.6020603179932 
Location:798-850IPR001879:HormR 
Evalue:-20.6575773191778 
Location:476-541IPR000832:G_PROTEIN_RECEP_F2_1 
Evalue:0 
Location:0-0
SequencesProtein: LPHN1_HUMAN (1474 aa)
mRNA: NM_001008701 NM_014921
Local Annotation
Synapse Ontology
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
some genes' expression is great dependent on the calcium, so calcium can regulate their expression.
sdb:0199 calcium regulation of transcription  (Evidence:keywords,domains)
KO assignmentK04592
  Level 3 annotation:
    latrophilin 1
  Level 2 annotation:
    G-protein coupled receptors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1293 residues, 14119550-14123427Exon2: 8 residues, 14123944-14123962Exon3: 45 residues, 14124120-14124249Exon4: 34 residues, 14124328-14124425Exon5: 45 residues, 14124595-14124724Exon6: 58 residues, 14127170-14127339Exon7: 32 residues, 14127921-14128013Exon8: 24 residues, 14128469-14128536Exon9: 75 residues, 14128736-14128957Exon10: 72 residues, 14129062-14129272Exon11: 59 residues, 14129693-14129864Exon12: 73 residues, 14130149-14130364Exon13: 44 residues, 14130901-14131027Exon14: 63 residues, 14131212-14131396Exon15: 15 residues, 14131546-14131585Exon16: 64 residues, 14131923-14132109Exon17: 36 residues, 14132404-14132508Exon18: 107 residues, 14133123-14133438Exon19: 269 residues, 14134417-14135218Exon20: 7 residues, 14138827-14138842Exon21: 38 residues, 14142493-14142603Exon22: 73 residues, 14149342-14149556Exon23: 57 residues, 14155344-14155509Exon24: 69 residues, 14177796-14177997Exon25: 2 residues, -Jump to LPHN1_HUMANExon1: 1293 residues, 14119550-14123427Exon2: 8 residues, 14123944-14123962Exon3: 45 residues, 14124120-14124249Exon4: 34 residues, 14124328-14124425Exon5: 45 residues, 14124595-14124724Exon6: 58 residues, 14127170-14127339Exon7: 32 residues, 14127921-14128013Exon8: 24 residues, 14128469-14128536Exon9: 75 residues, 14128736-14128957Exon10: 72 residues, 14129062-14129272Exon11: 59 residues, 14129693-14129864Exon12: 73 residues, 14130149-14130364Exon13: 44 residues, 14130901-14131027Exon14: 63 residues, 14131212-14131396Exon15: 15 residues, 14131546-14131585Exon16: 64 residues, 14131923-14132109Exon17: 36 residues, 14132404-14132508Exon18: 107 residues, 14133123-14133438Exon19: 269 residues, 14134417-14135218Exon20: 38 residues, 14142493-14142603Exon21: 73 residues, 14149342-14149556Exon22: 57 residues, 14155344-14155509Exon23: 69 residues, 14177796-14177997Exon24: 2 residues, -Jump to LPHN1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4372 14380630-14391171 ~-11K 18171(DDX39)(-)Loci: 3093 14430110-14443670 ~-14K 18178(+)Loci: 4373 14852137-14853264 ~-1K 18201(-)Loci: 4374 14921990-14944730 ~-23K 18203(SLC1A6)(-)Loci: 4375 15325340-15351603 ~-26K 18217(AKAP8)(-)Loci: 4376 15351858-15390833 ~-39K 18218(AKAP8L)(-)Loci: 3094 15699833-15700862 ~-1K 18230(OR10H2)(+)Loci: 4377 15778890-15779847 ~-1K 18231(OR10H1)(-)Loci: 3095 16083489-16105443 ~-22K 18238(RAB8A)(+)Loci: 3096 16169730-16207156 ~-37K 18242(AP1M1)(+)Loci: 4378 16333407-16443762 ~-110K 18245(EPS15L1)(-)Loci: 4371 14119550-14177997 ~-58K 18165(LPHN1)(-)Link out to UCSC