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0LIPB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLIPT1
DescriptionLipoyltransferase 1, mitochondrial precursor (ec 6.-.-.-) (lipoate- protein ligase) (lipoate biosynthesis protein) (lipoyl ligase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006629 lipid metabolism (TAS)
0006464 protein modification (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in biotin protein ligase.ipoate-protein ligase A and B. Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Each organism probably has only one BPL. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine . Lipoate-protein ligase A (LPLA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes .
  IPR004143:Biotin/lipoate A/B protein ligase
One member of this group of proteins is bovine lipoyltransferase.hich transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However.t does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group.ipoate-protein ligase A from Escherichia coli.atalyzes both the activation and the transfer of lipoate. Homology between the two is full-length.xcept for the bovine mitochondrial targeting signal.ut is strongest toward the N-terminus.
  IPR004562:Lipoyltransferase and lipoate-protein ligase
IPR004143:BPL_LipA_LipB 
Evalue:-20.2006587982178 
Location:74-157
SequencesProtein: LIPB_HUMAN (373 aa)
mRNA: NM_145197
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01976
  Level 3 annotation:
    
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 33 residues, 99137849-99137946Exon2: 44 residues, 99139195-99139321Exon3: 44 residues, 99139621-99139749Exon4: 399 residues, 99144851-99146043Exon5: 2 residues, -Jump to LIPB_HUMAN  
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