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0LIN7A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLIN7A
DescriptionLin-7 homolog a (lin-7a) (hlin-7) (mammalian lin-seven protein 1) (mals-1) (vertebrate lin 7 homolog 1) (veli-1 protein) (tax interaction protein 33) (tip-33).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0006887 exocytosis (TAS)
0006461 protein complex assembly (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
The L27 domain is found in receptor targeting proteins Lin-2 and Lin-7.s well as some protein kinases and human MPP2 protein.
  IPR004172:L27
IPR001478:PDZ 
Evalue:-22.8860566476932 
Location:116-190IPR004172:L27 
Evalue:-16.6989707946777 
Location:28-83
SequencesProtein: LIN7A_HUMAN (233 aa)
mRNA: NM_004664
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
interaction between synaptic vesicle and the scaffold.
sdb:0106 transport of synaptic vesicle in the presynaptic axon  (Evidence:keywords)
the plasma membrane is thicked into an active zone to which several synaptic vesicles are attached.
sdb:0151 active zone  (Evidence:keywords)
?
sdb:0247 cytoskeleton protein transport  (Evidence:keywords)
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
?
sdb:0297 NMDA receptor  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 112 residues, 79715301-79715636Exon2: 75 residues, 79729374-79729593Exon3: 72 residues, 79763639-79763849Exon4: 26 residues, 79766160-79766232Exon5: 41 residues, 79807160-79807279Exon6: 93 residues, 79855550-79855825Exon7: 2 residues, -Jump to LIN7A_HUMAN  
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