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0LIAS_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLIAS
DescriptionLipoic acid synthetase, mitochondrial precursor (lip-syn) (lipoate synthase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Radical SAM proteins catalyze diverse reactions.ncluding unusual methylations.somerization.ulphur insertion.ing formation.naerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S center .
  IPR007197:Radical SAM
This domain is found in MoaA.ifB.qqE.oproporphyrinogenIII oxidase.iotin synthase and MiaB families.nd includes a representative in the eukaryotic elongatorsubunit.lp-3. Some members of the family are methyltransferases .
  IPR006638:Elongator protein 3/MiaB/NifB
Lipoic acid is a covalently bound disulphide-containing cofactor required for function of the pyruvate dehydrogenase.lpha-ketoglutarate dehydrogenase.nd glycine cleavage enzyme complexes of Escherichia coli. Two genes.ipA and lipB.re involved in lipoic acid biosynthesis or metabolism. LipA is required for the insertion of the first sulphur into the octanoic acid backbone. LipB functions downstream of LipA.ut its role in lipoic acid metabolism remains unclear .Lipoate synthase (or lipoic acid synthetase) catalyses the formation of alpha-(+)-lipoic acid.equired for lipoate biosynthesis.
  IPR003698:Lipoate synthase
IPR007197:Radical_SAM 
Evalue:-25.408935546875 
Location:131-296
SequencesProtein: LIAS_HUMAN (372 aa)
mRNA: NM_006859
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 40 residues, 39137059-39137177Exon2: 59 residues, 39138804-39138977Exon3: 33 residues, 39140210-39140304Exon4: 29 residues, 39141539-39141620Exon5: 54 residues, 39143060-39143217Exon6: 21 residues, 39143299-39143357Exon7: 45 residues, 39145532-39145661Exon8: 50 residues, 39148033-39148179Exon9: 25 residues, 39149250-39149321Exon10: 39 residues, 39151114-39151226Exon11: 197 residues, 39155077-39155664Exon12: 2 residues, -Jump to LIAS_HUMAN  
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