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0LGMN_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLGMN
DescriptionLegumain precursor (ec 3.4.22.34) (asparaginyl endopeptidase) (protease, cysteine 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0001509 legumain activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Peptidases are grouped into clans and families. Clans are groups of families for which there is evidence of common ancestry. Families are grouped by their catalytic type.he first character representing the catalytic type: A.spartic; C.ysteine; G.lutamic acid; M.etallo; S.erine; T.hreonine; and U.nknown. A clan that contains families of more than one type is described as being of type P. The serine.hreonine and cysteine peptidases utilise the catalytic part of an amino acid as a nucleophile and form an acyl intermediate - these peptidases can also readily act as transferases. In the case of aspartic.lutamic and metallopeptidases.he nucleophile is an activated water molecule. Cysteine peptidases have characteristic molecular topologies.hich can be seen not only in their three-dimensional structures.ut commonly also in the two-dimensional structures. The peptidase domain is responsible for peptide bond hydrolysis; in Merops this is termed the peptidase unit. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related).nd further sub-divided into families.n the basis of the architecture of their catalytic dyad or triad : Clan CA contains the families of papain (C1).alpain (C2).treptopain (C10) and the ubiquitin-specific peptidases (C12.19).s well as many families of viral cysteine endopeptidases. Clan CD contains the families of clostripain (C11).ingipain R (C25).egumain (C13).aspase-1 (C14) and separin (C50). These enzymes have specificities dominated by the interactions of the S1 subsite. Clan CE contains the families of adenain (C5) from adenoviruses.he eukaryotic Ulp1 protease (C48) and the bacterial YopJ proteases (C55). Clan CF contains only pyroglutamyl peptidase I (C15). Clan PA contains the picornains (C3).hich have probably evolved from serine peptidases and which form the majority of enzymes in this clan. Clans PB and CH contain the autolytic cysteine peptidases. This group of cysteine peptidases belong to the MEROPS peptidase family C13 (legumain family.lan CD). A type example is legumain from Canavalia ensiformis. The blood fluke parasite Schistosoma mansoni has two cysteine proteases in its digestive tract.ne a cathepsin B-like protease.he other termed hemoglobinase . The latter has been hard to purify.ree of cathepsinB.nd expressed forms in Escherichia coli prove to be inactive.uggesting that hemoglobinase may act in association with cathepsin B . Plant vacuolar processing enzyme and legumain from legumes have been shown to havesequence and functional similarity to hemoglobinase. The catalytic residuesof the family are currently unknown.ut sequence alignments reveal onetotally conserved cysteine and two totally conserved histidines.
  IPR001096:Peptidase C13, legumain
IPR001096:Peptidase_C13 
Evalue:-268.420227050781 
Location:24-430
SequencesProtein: LGMN_HUMAN (433 aa)
mRNA: NM_001008530
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentK01369
  Level 3 annotation:
    legumain
  Level 2 annotation:
    Antigen processing and presentation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 184 residues, 92239909-92240459Exon2: 24 residues, 92240737-92240805Exon3: 59 residues, 92242580-92242751Exon4: 69 residues, 92245769-92245970Exon5: 32 residues, 92247756-92247846Exon6: 41 residues, 92247934-92248053Exon7: 24 residues, 92248902-92248969Exon8: 23 residues, 92249920-92249983Exon9: 27 residues, 92250473-92250549Exon10: 30 residues, 92252233-92252319Exon11: 29 residues, 92253477-92253559Exon12: 34 residues, 92254844-92254942Exon13: 57 residues, 92268746-92268913Exon14: 41 residues, 92277159-92277277Exon15: 61 residues, 92284586-92284765Exon16: 2 residues, -Jump to LGMN_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2859 92330402-92376057 ~-46K 11652(GOLGA5)(+)Loci: 4148 92239909-92284765 ~-45K 11649(LGMN)(-)Link out to UCSC