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0LETM1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLETM1
DescriptionLeucine zipper-ef-hand containing transmembrane protein 1, mitochondrial precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005739 mitochondrion (ISS)
0005509 calcium ion binding (TAS)
0007275 development (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1.uch as a transmembrane domain and a CK2 and PKC phosphorylation site .re relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans . A member of this family is known to be expressed in the mitochondria of Drosophila melanogaster .uggesting that this may be a group of mitochondrial proteins.
  IPR011685:LETM1-like
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR011685:LETM1 
Evalue:-176.552841186523 
Location:150-418IPR011992:EF-Hand_type 
Evalue:0 
Location:644-692
SequencesProtein: LETM1_HUMAN (739 aa)
mRNA: NM_012318
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 514 residues, 1784557-1786098Exon2: 48 residues, 1787188-1787327Exon3: 64 residues, 1788251-1788439Exon4: 47 residues, 1790862-1790997Exon5: 46 residues, 1793705-1793837Exon6: 50 residues, 1794512-1794656Exon7: 46 residues, 1795168-1795300Exon8: 42 residues, 1797088-1797208Exon9: 70 residues, 1804268-1804472Exon10: 48 residues, 1806369-1806507Exon11: 50 residues, 1807953-1808097Exon12: 152 residues, 1812871-1813322Exon13: 22 residues, 1820673-1820734Exon14: 128 residues, 1827393-1827772Exon15: 2 residues, -Jump to LETM1_HUMAN  
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Loci Cluster (Details)Loci: 4661 1784557-1827772 ~-43K 27218(LETM1)(-)Loci: 3399 2031384-2037433 ~-6K 27229(+)Loci: 3400 2440604-2487379 ~-47K 27243(RNF4)(+)Loci: 3398 1765420-1780396 ~-15K 27216(FGFR3)(+)Link out to UCSC