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0LCAT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameLCAT
DescriptionPhosphatidylcholine-sterol acyltransferase precursor (ec 2.3.1.43) (lecithin-cholesterol acyltransferase) (phospholipid-cholesterol acyltransferase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (NAS)
0004607 phosphatidylcholine-sterol O-acyltransferas... (NAS)
0005515 protein binding (IPI)
0008203 cholesterol metabolism (NAS)
0018350 protein amino acid esterification (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Lecithin:cholesterol acyltransferase (LACT) also known as phosphatidylcholine-sterol acyltransferase ().s involved in extracellular metabolism of plasma lipoproteins.ncluding cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins.nd is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases.
  IPR003386:Lecithin:cholesterol acyltransferase
IPR003386:LACT 
Evalue:-181.638275146484 
Location:81-408
SequencesProtein: LCAT_HUMAN (440 aa)
mRNA: NM_000229
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK00650
  Level 3 annotation:
    lecithin-cholesterol acyltransferase
  Level 2 annotation:
    Glycerophospholipid metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 199 residues, 66531287-66531882Exon2: 77 residues, 66533766-66533991Exon3: 34 residues, 66534074-66534170Exon4: 40 residues, 66534264-66534380Exon5: 54 residues, 66534459-66534616Exon6: 57 residues, 66535351-66535516Exon7: 2 residues, -Jump to LCAT_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2945 65471936-65479356 ~-7K 14263(PDP2)(+)Loci: 4230 65513089-65516920 ~-4K 14266(RRAD)(-)Loci: 4231 65767007-65774977 ~-8K 14287(-)Loci: 2946 66153964-66230588 ~-77K 14315(CTCF)(+)Loci: 2947 66252351-66254181 ~-2K 14321(PARD6A)(+)Loci: 4232 66531287-66535516 ~-4K 14345(LCAT)(-)Loci: 4233 66535730-66560026 ~-24K 14346(SLC12A4)(-)Loci: 4229 65102150-65141816 ~-40K 14239(TK2)(-)Link out to UCSC