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0KSR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKSR
DescriptionKinase suppressor of ras-1 (kinase suppressor of ras).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005622 intracellular (NAS)
0005524 ATP binding (NAS)
0004672 protein kinase activity (NAS)
0006468 protein amino acid phosphorylation (NAS)
0007265 Ras protein signal transduction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Protein kinases comprise a large family of enzymes that mediate the response of eukaryotic cells to external stimuli by phosphorylation of hydroxyamino acids. The enzymes fall into two broad classes.haracterised with respect to substrate specificity: serine/threonine specific and tyrosine specific . Tyrosine phosphorylating activity was originally detected in two viral transforming proteins .ut many retroviral transforming proteins and their cellular counterparts have since been shown to possess such activity. The growth factor receptors.hich are activated by ligand binding.nd theinsulin-related peptide receptor.re also family members.
  IPR001245:Tyrosine protein kinase
Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumor promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases.ollectively known as protein kinase C (PKC) . Phorbol esters can directly stimulate PKC. The N-terminal region of PKC.nown as C1.as been shown to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain.hich is about 50 amino-acid residues long.nd which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.
  IPR002219:Protein kinase C, phorbol ester/diacylglycerol binding
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR001245:Pkinase_Tyr 
Evalue:-39.040958404541 
Location:611-875IPR002219:C1 
Evalue:-6.72124639904717 
Location:346-389
SequencesProtein: KSR1_HUMAN (921 aa)
mRNA: NM_014238
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 24 residues, 22823162-22823233Exon2: 66 residues, 22834810-22835004Exon3: 49 residues, 22901720-22901861Exon4: 51 residues, 22928644-22928792Exon5: 156 residues, 22933798-22934260Exon6: 23 residues, 22939624-22939688Exon7: 30 residues, 22941963-22942047Exon8: 22 residues, 22943513-22943575Exon9: 37 residues, 22943672-22943779Exon10: 58 residues, 22948420-22948589Exon11: 16 residues, 22952512-22952554Exon12: 24 residues, 22953045-22953111Exon13: 20 residues, 22954986-22955041Exon14: 18 residues, 22955832-22955881Exon15: 128 residues, 22956586-22956966Exon16: 34 residues, 22959066-22959163Exon17: 46 residues, 22960348-22960482Exon18: 46 residues, 22961219-22961351Exon19: 47 residues, 22962646-22962782Exon20: 46 residues, 22968447-22968581Exon21: 589 residues, 22973081-22974844Exon22: 2 residues, -Jump to KSR1_HUMAN  
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