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0KS6B1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRPS6KB1
DescriptionRibosomal protein s6 kinase 1 (ec 2.7.1.37) (s6k) (s6k1) (70 kda ribosomal protein s6 kinase 1) (p70 s6 kinase alpha) (p70(s6k)-alpha) (p70-s6k) (p70-alpha).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004672 protein kinase activity (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases are responsible for the phosphorylation of proteins.otentially for regulating their activity. This domain is found in a large variety of protein kinases with different functions and dependencies. Protein kinase C.or example.s a calcium-activated.hospholipid-dependent serine- and threonine-specific enzyme. It is activated by diacylglycerol which.n turn.hosphorylates a range ofcellular proteins. This domain is most often found associated with .
  IPR000961:Protein kinase, C-terminal
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-106.096910013008 
Location:91-352IPR000961:S_TK_X 
Evalue:-26.0506099933551 
Location:353-415
SequencesProtein: KS6B1_HUMAN (525 aa)
mRNA: BC036033 NM_003161
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK04688
  Level 3 annotation:
    p70 ribosomal S6 kinase
  Level 2 annotation:
    TGF-beta signaling pathway
    Insulin signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 82 residues, 55325224-55325468Exon2: 18 residues, 55342704-55342754Exon3: 42 residues, 55344826-55344947Exon4: 25 residues, 55346777-55346846Exon5: 51 residues, 55358577-55358725Exon6: 21 residues, 55362259-55362317Exon7: 35 residues, 55363764-55363865Exon8: 32 residues, 55366312-55366403Exon9: 32 residues, 55366576-55366667Exon10: 38 residues, 55367335-55367443Exon11: 23 residues, 55368357-55368420Exon12: 28 residues, 55368606-55368684Exon13: 38 residues, 55372978-55373086Exon14: 39 residues, 55377548-55377661Exon15: 1293 residues, 55378693-55382566Exon16: 2 residues, -Jump to KS6B1_HUMANExon1: 81 residues, 55325228-55325468Exon2: 18 residues, 55342704-55342754Exon3: 42 residues, 55344826-55344947Exon4: 25 residues, 55346777-55346846Exon5: 57 residues, 55358558-55358725Exon6: 21 residues, 55362259-55362317Exon7: 86 residues, 55362942-55363195Exon8: 35 residues, 55363764-55363865Exon9: 32 residues, 55366312-55366403Exon10: 32 residues, 55366576-55366667Exon11: 38 residues, 55367335-55367443Exon12: 111 residues, 55368357-55368684Exon13: 38 residues, 55372978-55373086Exon14: 39 residues, 55377548-55377661Exon15: 305 residues, 55378693-55379602Exon16: 2 residues, -Jump to KS6B1_HUMAN  
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