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0KS6A4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRPS6KA4
DescriptionRibosomal protein s6 kinase alpha 4 (ec 2.7.1.37) (nuclear mitogen-and stress-activated protein kinase 2) (90 kda ribosomal protein s6 kinase 4) (ribosomal protein kinase b) (rskb).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (IDA)
0005524 ATP binding (IDA)
0048273 mitogen-activated protein kinase p38 binding (IGI)
0005515 protein binding (IPI)
0004711 ribosomal protein S6 kinase activity (NAS)
0006468 protein amino acid phosphorylation (IDA)
0007243 protein kinase cascade (IDA)
0006355 regulation of transcription, DNA-dependent (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Protein kinases are responsible for the phosphorylation of proteins.otentially for regulating their activity. This domain is found in a large variety of protein kinases with different functions and dependencies. Protein kinase C.or example.s a calcium-activated.hospholipid-dependent serine- and threonine-specific enzyme. It is activated by diacylglycerol which.n turn.hosphorylates a range ofcellular proteins. This domain is most often found associated with .
  IPR000961:Protein kinase, C-terminal
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-98.6777807052661 
Location:33-301IPR002290:S_TKc 
Evalue:-86.8860566476932 
Location:411-674IPR000961:S_TK_X 
Evalue:-13.1366771398795 
Location:302-363
SequencesProtein: KS6A4_HUMAN (772 aa)
mRNA: NM_001006944 NM_003942
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
KO assignmentK04445
  Level 3 annotation:
    mitogen-,stress activated protein kinases
  Level 2 annotation:
    MAPK signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 47 residues, 63883200-63883338Exon2: 26 residues, 63883425-63883497Exon3: 75 residues, 63884210-63884429Exon4: 40 residues, 63884524-63884640Exon5: 38 residues, 63885181-63885289Exon6: 29 residues, 63885516-63885597Exon7: 36 residues, 63885689-63885793Exon8: 52 residues, 63885899-63886050Exon9: 57 residues, 63889348-63889513Exon10: 45 residues, 63892179-63892308Exon11: 46 residues, 63892515-63892649Exon12: 33 residues, 63892751-63892845Exon13: 60 residues, 63893493-63893667Exon14: 67 residues, 63893746-63893941Exon15: 55 residues, 63894272-63894432Exon16: 56 residues, 63894610-63894774Exon17: 312 residues, 63895330-63896262Exon18: 2 residues, -Jump to KS6A4_HUMANExon1: 47 residues, 63883200-63883338Exon2: 26 residues, 63883425-63883497Exon3: 75 residues, 63884210-63884429Exon4: 40 residues, 63884524-63884640Exon5: 38 residues, 63885181-63885289Exon6: 29 residues, 63885516-63885597Exon7: 36 residues, 63885689-63885793Exon8: 52 residues, 63885899-63886050Exon9: 57 residues, 63889348-63889513Exon10: 45 residues, 63892179-63892308Exon11: 40 residues, 63892533-63892649Exon12: 33 residues, 63892751-63892845Exon13: 60 residues, 63893493-63893667Exon14: 67 residues, 63893746-63893941Exon15: 55 residues, 63894272-63894432Exon16: 56 residues, 63894610-63894774Exon17: 312 residues, 63895330-63896262Exon18: 2 residues, -Jump to KS6A4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2672 63498654-63500590 ~-2K 6992(COX8A)(+)Loci: 2673 63758841-63762834 ~-4K 7008(VEGFB)(+)Loci: 2674 63775570-63791969 ~-16K 7011(PLCB3)(+)Loci: 2675 63883200-63896262 ~-13K 7031(RPS6KA4)(+)Loci: 3958 64130223-64247236 ~-117K 7042(NRXN2)(-)Loci: 3959 64376783-64402767 ~-26K 7059(EHD1)(-)Loci: 2676 64551485-64564618 ~-13K 7071(SNX15)(+)Loci: 2677 64635935-64640274 ~-4K 7081(TM7SF2)(+)Loci: 2678 64705918-64736052 ~-30K 7088(CAPN1)(+)Loci: 2679 65049159-65062750 ~-14K 7102(+)Loci: 3960 65121802-65138296 ~-16K 7115(MAP3K11)(-)Loci: 3961 65407787-65412586 ~-5K 7136(FIBP)(-)Loci: 3962 65416267-65424573 ~-8K 7139(FOSL1)(-)Loci: 2680 65594399-65768789 ~-174K 7153(PACS1)(+)Loci: 2681 65792680-65801537 ~-9K 7155(RAB1B)(+)Loci: 2682 65815916-65820707 ~-5K 7159(+)Loci: 3963 65856117-65860576 ~-4K 7162(RIN1)(-)Loci: 2683 66140672-66151387 ~-11K 7189(RBM14)(+)Loci: 2684 66162753-66170514 ~-8K 7192(RBM4)(+)Loci: 3964 66209298-66245446 ~-36K 7194(SPTBN2)(-)Loci: 3965 66372572-66478456 ~-106K 7198(PC)(-)Loci: 2685 66547466-66574905 ~-27K 7200(SYT12)(+)Loci: 2686 66580896-66596059 ~-15K 7201(RHOD)(+)Loci: 3966 66922227-66925952 ~-4K 7219(PPP1CA)(-)Loci: 2687 66979393-66983261 ~-4K 7229(CABP4)(+)Loci: 2688 67130982-67136581 ~-6K 7239(NDUFV1)(+)Loci: 2689 67554684-67560690 ~-6K 7248(NDUFS8)(+)Loci: 2690 67836710-67973317 ~-137K 7259(LRP5)(+)Loci: 2671 63412650-63433621 ~-21K 6988(MARK2)(+)Link out to UCSC