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0KRHB4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionKeratin, type ii cuticular hb4 (hair keratin, type ii hb4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030280 structural constituent of epidermis (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Intermediate filaments (IF) are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide.IF proteins are members of a very large multigene family of proteins which has been subdivided in five major subgroups:Type I: Acidic cytokeratins.Type II: Basic cytokeratins.Type III: Vimentin.esmin.lial fibrillary acidic protein (GFAP).eripherin.nd plasticin.Type IV: Neurofilaments L. and M.lpha-internexin and nestin.Type V: Nuclear lamins A.1.2 and C.All IF proteins are structurally similar in that they consist of: a central rod domain comprising some 300 to 350 residues which is arranged in coiled-coiled alpha-helices.ith at least two short characteristic interruptions; a N-terminal non-helical domain (head) of variable length; and a C-terminal domain (tail) which is also non-helical.nd which shows extreme length variation between different IF proteins.While IF proteins are evolutionary and structurally related.hey have limited sequence homologies except in several regions of the rod domain.
  IPR001664:Intermediate filament protein
Keratins are a well known group of intermediate filament proteins. Like actin filaments.eratins are flexible but provide a firm cell skeleton.Unlike actin.owever.o known keratins are associated with motor functions. Approximately 10 keratins form the basis of hair or claw.ith a further 20 found in internal body cavity epithelia. They are alsofound at desmosomes and hemi-desmosomes (cell/cell and cell/matrix contacts respectively) .Type I keratins are a group of acidic intermediate filament proteins thatexist as chains of hetero-dimers with basic type II keratins. Each typeI keratin consists of head-.od- and tail-like structures.he rod beingconstructed from three linked coils: 1A.B and 2. Type I proteins are associated with a number of inherited developmental disorders.uch as baldness.eading of hair.nd skin blistering.
  IPR002957:Keratin, type I
Intermediate filaments (IF) are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide. Type II keratins are the basic or neutral courterparts to the acidic type I keratins. Each type II keratin forms a heterodimer with a specific acidic keratin.nd the heterodimers are organised into tetramers and then into chains . Type II keratins consist of head-.od- and tail-like structures.he rod being constructed from three linked coils: 1A.B and 2. The head and tail structures of the type 2 keratins are highly variable low-complexity regions.
  IPR003054:Type II keratin
This domain consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011000:Apolipophorin III-like
SequencesProtein: KRHB4_HUMAN (600 aa)
mRNA: BC069647
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
KO assignmentK07605
  Level 3 annotation:
    type II keratin, basic
  Level 2 annotation:
    Membrane and intracellular structural molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 190 residues, 51057862-51058431Exon2: 12 residues, 51059926-51059958Exon3: 75 residues, 51060413-51060634Exon4: 44 residues, 51061130-51061256Exon5: 57 residues, 51061411-51061576Exon6: 34 residues, 51062487-51062583Exon7: 22 residues, 51063055-51063116Exon8: 71 residues, 51063640-51063849Exon9: 200 residues, 51065090-51065684Exon10: 2 residues, -Jump to KRHB4_HUMAN  
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Loci Cluster (Details)Loci: 2755 50587468-50601120 ~-14K 8882(ACVRL1)(+)Loci: 2756 50631752-50677126 ~-45K 8883(ACVR1B)(+)Loci: 2757 50687014-50695938 ~-9K 8886(GRASP)(+)Loci: 4034 50965965-50971566 ~-6K 8896(KRTHB1)(-)Loci: 2758 50981917-50988684 ~-7K 8897(KRTHB6)(+)Loci: 4035 50994358-51001438 ~-7K 8898(KRTHB3)(-)Loci: 4036 51040058-51047576 ~-8K 8899(KRTHB5)(-)Loci: 4037 51057862-51065684 ~-8K 8900(KRTHB4)(-)Loci: 4038 51104120-51114373 ~-10K 8902(-)Loci: 4039 51148861-51153824 ~-5K 8903(KRT6D)(-)Loci: 4040 51167243-51173287 ~-6K 8904(KRT6A)(-)Loci: 4041 51194627-51200510 ~-6K 8905(KRT5)(-)Loci: 4042 51265639-51281559 ~-16K 8909(-)Loci: 4043 51448205-51457372 ~-9K 8917(KRT2P)(-)Loci: 4044 51486600-51494602 ~-8K 8920(KRT4)(-)Loci: 4045 51577237-51585127 ~-8K 8924(KRT8)(-)Loci: 2759 51629109-51632951 ~-4K 8926(KRT18)(+)Loci: 2761 51948817-51973697 ~-25K 8948(ESPL1)(+)Loci: 4046 52160546-52179538 ~-19K 8970(MAP3K12)(-)Loci: 4047 52186740-52187689 ~-1K 8973(NPFF)(-)Loci: 4048 52345211-52356779 ~-12K 8978(ATP5G2)(-)Loci: 2754 50271286-50488365 ~-217K 8878(SCN8A)(+)Link out to UCSC