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0KLRF1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKLRF1
DescriptionKiller cell lectin-like receptor subfamily f member 1 (lectin-like receptor f1) (activating coreceptor nkp80).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0016020 membrane (TAS)
0030106 MHC class I receptor activity (TAS)
0019735 antimicrobial humoral response (sensu Verte... (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Animal lectins display a wide variety of architectures.They are classified according to the carbohydrate-recognitiondomain (CRD) of which there are two main types.-type and C-type .C-type lectins display a wide range of specificities.They require Ca2+ for their activityThey are found predominantly but not exclusively in vertebrates.They can be classified into a number of subgroups based on their function and structure: Endocytic lectins - Membrane-bound receptors that mediate endocytosis of glycoproteins Collectins - Represented by the soluble mannose-binding proteins of mammalian serum and liver Selectins - Membrane-bound proteins involved in inflammation .D22 (also called BL-CAM or Lyb8) are adhesion and signaling molecules. Targeted disruption of CD22 in mice results in a reduced level of surface IgM on peripheral B cells.nhanced Ca2+ flux in response to Ig signaling.ariable proliferative responses to surface Ig crosslinking. Several studies observed a reduced response to thymus independent antigens. The CD22-knockout data support a role for CD22 in limiting antigen receptor signaling although a positive role in certain B cell response cannot be excluded. CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR001304:C-type lectin
Marine teleosts from polar oceans can be protected from freezing in icysea-water by serum antifreeze proteins (AFPs) or glycoproteins (AFGPs) .These function by binding to.nd preventing the growth of.ce crystalswithin the fish. Despite functional similarity.he proteins arestructurally diverse and include glycosylated and at least 3 non-glycosylated forms: the AFGP of nototheniids and cod are polymers of atripeptide repeat.la-Ala-Thr.ith a disaccharide attached to thethreonine residue; type I AFPs are Ala-rich.lpha-helical peptidesfound in flounder and sculpin; type II AFPs of sea-raven.melt andherring are Cys-rich proteins; and type III AFPs.ound in eel pouts.re rich in beta-structure. Although no direct structural information is available for type II AFPs.heir sequences are similar to the carbohydrate recognition domain (CRD)of Ca2+-dependent lectins. This domain is present in a superfamily ofproteins that bind sugars specifically through contact with a calciumion. The extent of similarity within the superfamily is confined to short motifs and single amino acids at intervals throughout the protein.
  IPR002353:Type II antifreeze protein
IPR001304:CLECT 
Evalue:-26.6777807052661 
Location:114-230IPR001304:C_TYPE_LECTIN_1 
Evalue:0 
Location:0-0
SequencesProtein: KLRF1_HUMAN (231 aa)
mRNA: NM_016523
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 50 residues, 9871343-9871492Exon2: 35 residues, 9876178-9876277Exon3: 52 residues, 9877165-9877315Exon4: 49 residues, 9885674-9885817Exon5: 39 residues, 9886186-9886299Exon6: 197 residues, 9888283-9888868Exon7: 2 residues, -Jump to KLRF1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2737 10256755-10266989 ~-10K 8391(GABARAPL1)(+)Loci: 2736 9871343-9888868 ~-18K 8359(KLRF1)(+)Link out to UCSC