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0KLOT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKL
DescriptionKlotho precursor (ec 3.2.1.31) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005615 extracellular space (TAS)
0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0005625 soluble fraction (TAS)
0008422 beta-glucosidase activity (TAS)
0004871 signal transducer activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.Glycoside hydrolase family 1 comprises enzymes with a number of known activities; beta-glucosidase (); beta-galactosidase (); 6-phospho-beta-galactosidase (); 6-phospho-beta-glucosidase (); lactase-phlorizin hydrolase ().); beta-mannosidase (); myrosinase ().
  IPR001360:Glycoside hydrolase, family 1
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.Glycoside hydrolase family 1 comprises enzymes with a number of known activities; beta-glucosidase (); beta-galactosidase (); 6-phospho-beta-galactosidase (); 6-phospho-beta-glucosidase (); lactase-phlorizin hydrolase ().); beta-mannosidase (); myrosinase (). This family consists of a group of glycoside hydrolase family 1 members which are found only in eukaryotes.
  IPR011580:6-phospho-beta-galactosidase, eukaryotic
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.This entry represents the catalytic TIM beta/alpha barrel common to many different families of glycosyl hydrolases. Structures have been determined for several proteins containing this domain.ncluding family 13 glycosyl hydrolases (such as alpha-amylase) .eta-glycanases .amily 1 glycosyl hydrolases (such as beta-glucosidase) .ype II chitinases ..-beta-N-acetylmuraminidases .nd beta-N-acetylhexosaminidases .More information about this protein can be found at Protein of the Month: alpha-Amylase .
  IPR013781:Glycoside hydrolase, catalytic core
IPR001360:Glyco_hydro_1 
Evalue:-152.481491088867 
Location:57-506IPR001360:Glyco_hydro_1 
Evalue:-52.2518119812012 
Location:697-919IPR001360:GLYCOSYL_HYDROL_F1_1 
Evalue:0 
Location:0-0
SequencesProtein: KLOT_HUMAN (1012 aa)
mRNA: NM_004795
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 276 residues, 32488570-32489397Exon2: 172 residues, 32525903-32526414Exon3: 91 residues, 32527183-32527452Exon4: 369 residues, 32532815-32533917Exon5: 766 residues, 32535985-32538279Exon6: 2 residues, -Jump to KLOT_HUMAN  
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